dc.contributor.author |
Betts, Joshua A |
en |
dc.contributor.author |
Moradi Marjaneh, Mahdi |
en |
dc.contributor.author |
Al-Ejeh, Fares |
en |
dc.contributor.author |
Lim, Yi Chieh |
en |
dc.contributor.author |
Shi, Wei |
en |
dc.contributor.author |
Sivakumaran, Haran |
en |
dc.contributor.author |
Tropée, Romain |
en |
dc.contributor.author |
Patch, Ann-Marie |
en |
dc.contributor.author |
Clark, Michael B |
en |
dc.contributor.author |
Bartonicek, Nenad |
en |
dc.contributor.author |
Wiegmans, Adrian P |
en |
dc.contributor.author |
Hillman, Kristine M |
en |
dc.contributor.author |
Kaufmann, Susanne |
en |
dc.contributor.author |
Bain, Amanda L |
en |
dc.contributor.author |
Gloss, Brian S |
en |
dc.contributor.author |
Crawford, Joanna |
en |
dc.contributor.author |
Kazakoff, Stephen |
en |
dc.contributor.author |
Wani, Shivangi |
en |
dc.contributor.author |
Wen, Shu W |
en |
dc.contributor.author |
Day, Bryan |
en |
dc.contributor.author |
Möller, Andreas |
en |
dc.contributor.author |
Cloonan, Nicole |
en |
dc.contributor.author |
Pearson, John |
en |
dc.contributor.author |
Brown, Melissa A |
en |
dc.contributor.author |
Mercer, Timothy R |
en |
dc.contributor.author |
Waddell, Nicola |
en |
dc.contributor.author |
Khanna, Kum Kum |
en |
dc.contributor.author |
Dray, Eloise |
en |
dc.contributor.author |
Dinger, Marcel E |
en |
dc.contributor.author |
Edwards, Stacey L |
en |
dc.contributor.author |
French, Juliet D |
en |
dc.date.accessioned |
2018-11-15T02:34:54Z |
en |
dc.date.issued |
2017-08 |
en |
dc.identifier.issn |
0002-9297 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/44306 |
en |
dc.description.abstract |
Breast cancer risk is strongly associated with an intergenic region on 11q13. We have previously shown that the strongest risk-associated SNPs fall within a distal enhancer that regulates CCND1. Here, we report that, in addition to regulating CCND1, this enhancer regulates two estrogen-regulated long noncoding RNAs, CUPID1 and CUPID2. We provide evidence that the risk-associated SNPs are associated with reduced chromatin looping between the enhancer and the CUPID1 and CUPID2 bidirectional promoter. We further show that CUPID1 and CUPID2 are predominantly expressed in hormone-receptor-positive breast tumors and play a role in modulating pathway choice for the repair of double-strand breaks. These data reveal a mechanism for the involvement of this region in breast cancer. |
en |
dc.format.medium |
Print |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
American journal of human genetics |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Cell Line, Tumor |
en |
dc.subject |
Chromosomes, Human, Pair 11 |
en |
dc.subject |
Chromatin |
en |
dc.subject |
Humans |
en |
dc.subject |
Breast Neoplasms |
en |
dc.subject |
DNA Damage |
en |
dc.subject |
Genetic Predisposition to Disease |
en |
dc.subject |
Cyclin D1 |
en |
dc.subject |
RNA, Small Interfering |
en |
dc.subject |
RNA, Guide |
en |
dc.subject |
Estrogens |
en |
dc.subject |
DNA Repair |
en |
dc.subject |
Gene Expression Regulation, Neoplastic |
en |
dc.subject |
RNA Interference |
en |
dc.subject |
Polymorphism, Single Nucleotide |
en |
dc.subject |
Female |
en |
dc.subject |
DNA Breaks, Double-Stranded |
en |
dc.subject |
Enhancer Elements, Genetic |
en |
dc.subject |
Promoter Regions, Genetic |
en |
dc.subject |
MCF-7 Cells |
en |
dc.subject |
RNA, Long Noncoding |
en |
dc.title |
Long Noncoding RNAs CUPID1 and CUPID2 Mediate Breast Cancer Risk at 11q13 by Modulating the Response to DNA Damage. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.ajhg.2017.07.007 |
en |
pubs.issue |
2 |
en |
pubs.begin-page |
255 |
en |
pubs.volume |
101 |
en |
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
28777932 |
en |
pubs.end-page |
266 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
research-article |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
649196 |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Biological Sciences |
en |
dc.identifier.eissn |
1537-6605 |
en |
pubs.record-created-at-source-date |
2017-08-05 |
en |
pubs.dimensions-id |
28777932 |
en |