Abstract:
Goals of work The beneficial effects of exercise in cancer patients are reasonably well-established, although research in thisfieldhaspredominantlyinvestigatedcancerpatientsinthe earlier stages of disease. However, the most recent evidence surrounding exercise interventions in advanced cancer populations has yet to be systematically evaluated. This review critically analyses the safety and feasibility of exercise interventions in patients with advanced cancer. Methods All randomised, non-randomised and prospective observational trials of exercise training interventions in patients with advanced cancer were included. ‘Safety’ was defined as the number and severity of reported adverse events during exercise training. ‘Feasibility’ was determined by participant adherence, attendance and/or study completion rates. Results A total of 25 studies involving 1088 patients were included: 16 randomised controlled and nine prospective observational cohort trials. Seven studies included advanced lungcancerpatientsexclusively,whileeight involvedpatients with various cancer diagnoses. Aerobic exercise was investigated in five studies, resistance training in two studies and combination training (aerobic and resistance) in 14 studies. Six minor adverse events were reported due to exercise. All of these were musculoskeletal in nature, resulting in two participants’ withdrawal from the study. Exercise adherence rangedfrom65to89%butwasonlydescribedinninestudies. Attendanceateachexercisesessionwasdescribedinafurther nine studies, ranging from 59 to 100%. Conclusions Implementation of exercise interventions appears to be safe and feasible in advanced cancer clinical practice, although targeted studies are required to determine the optimal exercise dose for specific cancer diagnoses.