dc.contributor.author |
Garrett, Amy S |
en |
dc.contributor.author |
Pham, Toan |
en |
dc.contributor.author |
Loiselle, Denis |
en |
dc.contributor.author |
June-Chiew Han |
en |
dc.contributor.author |
Taberner, Andrew |
en |
dc.date.accessioned |
2018-11-18T20:53:35Z |
en |
dc.date.issued |
2017-07 |
en |
dc.identifier.citation |
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 2017: 1287-1290. Jul 2017 |
en |
dc.identifier.issn |
1557-170X |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/44361 |
en |
dc.description.abstract |
The performance of mechanical work by isolated cardiac muscle samples has typically been studied by subjecting their tissues to an isotonic shortening protocol, which results in "flat-topped" work-loop profiles. In order to better replicate the forces experienced by these tissues in vivo, we have developed a system for imposing a model-based, time-varying, load on isolated cardiac tissue preparations. A model of systemic afterload was developed from the combination of a Windkessel-type model of vascular fluid impedance, and the Laplace law of the heart, and encoded into a hardware-based control system. The model-predicted length change was then imposed on an isolated cardiac trabecula in a work-loop calorimeter, giving rise to force-length work-loops that more closely resemble those experienced by these tissues in vivo. |
en |
dc.format.medium |
Print |
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dc.relation.ispartofseries |
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
https://www.ieee.org/publications/rights/author-posting-policy.html |
en |
dc.subject |
Myocardium |
en |
dc.subject |
Heart |
en |
dc.subject |
Myocardial Contraction |
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dc.subject |
Hemodynamics |
en |
dc.title |
Real-time model-based control of afterload for in vitro cardiac tissue experimentation. |
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dc.type |
Conference Item |
en |
dc.identifier.doi |
10.1109/embc.2017.8037067 |
en |
pubs.begin-page |
1287 |
en |
pubs.volume |
2017 |
en |
dc.rights.holder |
Copyright: IEEE |
en |
dc.identifier.pmid |
29060111 |
en |
pubs.end-page |
1290 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.elements-id |
702062 |
en |
pubs.org-id |
Bioengineering Institute |
en |
pubs.org-id |
ABI Associates |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Nutrition |
en |
pubs.record-created-at-source-date |
2017-10-25 |
en |
pubs.dimensions-id |
29060111 |
en |