Humidification mitigates acute mucosal toxicity during radiotherapy when factoring volumetric parameters. Trans Tasman Radiation Oncology Group (TROG) RadioHUM 07.03 substudy

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dc.contributor.author Macann, Andrew en
dc.contributor.author Fauzi, F en
dc.contributor.author Simpson, J en
dc.contributor.author Sasso, G en
dc.contributor.author Krawitz, H en
dc.contributor.author Fraser-Browne, C en
dc.contributor.author Manitz, J en
dc.contributor.author Raith, Andrea en
dc.date.accessioned 2018-11-18T23:12:41Z en
dc.date.issued 2017-12 en
dc.identifier.citation Oral Oncology 75:75-80 Dec 2017 en
dc.identifier.issn 1368-8375 en
dc.identifier.uri http://hdl.handle.net/2292/44399 en
dc.description.abstract PURPOSE/OBJECTIVE(S): To model in a subset of patients from TROG 07.03 managed at a single site the association between domiciliary based humidification use and mucositis symptom burden during radiotherapy (RT) for head and neck cancer (HNC) when factoring in volumetric radiotherapy parameters derived from tumour and normal tissue regions of interest. MATERIALS/METHODS: From June 2008 through June 2011, 210 patients with HNC receiving RT were randomised to either a control arm or humidification using the Fisher & Paykel Healthcare MR880 humidifier. This subset analysis involves patients recruited from Auckland City Hospital treated with a prescribed dose of ≥70 Gy. Regression models included control variables for Planning Target Volume 70 GY (PTV70Gy); Equivalent Uniform Dose (EUD) MOIST and TSV (surrogates of total mucosal and total swallowing volumes respectively). RESULTS: The analysis included 39 patients (humidification 20, control 19). There was a significant odds reduction in CTCAE v3.0 functional mucositis score of 0.29 associated with the use of humidification (p<.001). Within the parameters of the model therefore, the risk of a humidification patient being scored as experiencing a one-step increase in functional mucositis was 3.45 times lower (1/0.29) than for control patients. A control patient was 4.17 times more likely to receive an unfavourable nutritional mode score (p<.001). The risk of being admitted to hospital decreased by a factor of 11.11 for humidification patients (p=.013). CONCLUSION: The results support the hypothesis that humidification can help mitigate mucositis symptom burden. Radiotherapy dosimetric parameters assist in the evaluation of toxicity interventions. en
dc.publisher Elsevier en
dc.relation.ispartofseries Oral Oncology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.title Humidification mitigates acute mucosal toxicity during radiotherapy when factoring volumetric parameters. Trans Tasman Radiation Oncology Group (TROG) RadioHUM 07.03 substudy en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.oraloncology.2017.10.021 en
pubs.begin-page 75 en
pubs.volume 75 en
dc.rights.holder Copyright: Elsevier en
dc.identifier.pmid 29224827 en
pubs.end-page 80 en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Article en
pubs.elements-id 708825 en
pubs.org-id Engineering en
pubs.org-id Engineering Science en
dc.identifier.eissn 1879-0593 en
dc.identifier.pii S1368-8375(17)30347-0 en
pubs.record-created-at-source-date 2017-11-08 en
pubs.online-publication-date 2017-11-01 en
pubs.dimensions-id 29224827 en


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https://creativecommons.org/licenses/by-nc-nd/4.0/ Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc-nd/4.0/

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