Recent developments in anticancer drug delivery using cell penetrating and tumor targeting peptides.

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dc.contributor.author Dissanayake, Shama en
dc.contributor.author Denny, William en
dc.contributor.author Gamage, Swarnalatha en
dc.contributor.author Sarojini Amma, Vijayalekshmi en
dc.date.accessioned 2018-11-19T00:17:46Z en
dc.date.issued 2017-03 en
dc.identifier.issn 1873-4995 en
dc.identifier.uri http://hdl.handle.net/2292/44428 en
dc.description.abstract Efficient intracellular trafficking and targeted delivery to the site of action are essential to overcome the current drawbacks of cancer therapeutics. Cell Penetrating Peptides (CPPs) offer the possibility of efficient intracellular trafficking, and, therefore the development of drug delivery systems using CPPs as cargo carriers is an attractive strategy to address the current drawbacks of cancer therapeutics. Additionally, the possibility of incorporating Tumor Targeting Peptides (TTPs) into the delivery system provides the necessary drug targeting effect. Therefore the conjugation of CPPs and/or TTPs with therapeutics provides a potentially efficient method of improving intracellular drug delivery mechanisms. Peptides used as cargo carriers in DDS have been shown to enhance the cellular uptake of drugs and thereby provide an efficient therapeutic benefit over the drug on its own. After providing a brief overview of various drug targeting approaches, this review focusses on peptides as carriers and targeting moieties in drug-peptide covalent conjugates and summarizes the most recent literature examples where CPPs on their own or CPPs together with TTPs have been conjugated to anticancer drugs such as Doxorubicin, Methotrexate, Paclitaxel, Chlorambucil etc. A short section on CPPs used in multicomponent drug delivery systems is also included. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Journal of controlled release : official journal of the Controlled Release Society en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Animals en
dc.subject Humans en
dc.subject Neoplasms en
dc.subject Peptides en
dc.subject Antineoplastic Agents en
dc.subject Drug Carriers en
dc.subject Biological Transport en
dc.subject Cell-Penetrating Peptides en
dc.subject Drug Liberation en
dc.title Recent developments in anticancer drug delivery using cell penetrating and tumor targeting peptides. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.jconrel.2017.02.006 en
pubs.begin-page 62 en
pubs.volume 250 en
dc.rights.holder Copyright: The author en
dc.identifier.pmid 28167286 en
pubs.end-page 76 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Review en
pubs.subtype Journal Article en
pubs.elements-id 612753 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Auckland Cancer Research en
pubs.org-id Science en
pubs.org-id Chemistry en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1873-4995 en
pubs.record-created-at-source-date 2017-02-08 en
pubs.dimensions-id 28167286 en


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