Treating depression with physical activity in adolescents and young adults: a systematic review and meta-analysis of randomised controlled trials.

Show simple item record Bailey, AP en Hetrick, Sarah en Rosenbaum, S en Purcell, R en Parker, AG en 2018-11-21T02:39:38Z en 2018-05 en
dc.identifier.citation Psychological medicine 48(7):1068-1083 May 2018 en
dc.identifier.issn 0033-2917 en
dc.identifier.uri en
dc.description.abstract We aimed to establish the treatment effect of physical activity for depression in young people through meta-analysis. Four databases were searched to September 2016 for randomised controlled trials of physical activity interventions for adolescents and young adults, 12-25 years, experiencing a diagnosis or threshold symptoms of depression. Random-effects meta-analysis was used to estimate the standardised mean difference (SMD) between physical activity and control conditions. Subgroup analysis and meta-regression investigated potential treatment effect modifiers. Acceptability was estimated using dropout. Trials were assessed against risk of bias domains and overall quality of evidence was assessed using GRADE criteria. Seventeen trials were eligible and 16 provided data from 771 participants showing a large effect of physical activity on depression symptoms compared to controls (SMD = -0.82, 95% CI = -1.02 to -0.61, p < 0.05, I2 = 38%). The effect remained robust in trials with clinical samples (k = 5, SMD = -0.72, 95% CI = -1.15 to -0.30), and in trials using attention/activity placebo controls (k = 7, SMD = -0.82, 95% CI = -1.05 to -0.59). Dropout was 11% across physical activity arms and equivalent in controls (k = 12, RD = -0.01, 95% CI = -0.04 to 0.03, p = 0.70). However, the quality of RCT-level evidence contributing to the primary analysis was downgraded two levels to LOW (trial-level risk of bias, suspected publication bias), suggesting uncertainty in the size of effect and caution in its interpretation. While physical activity appears to be a promising and acceptable intervention for adolescents and young adults experiencing depression, robust clinical effectiveness trials that minimise risk of bias are required to increase confidence in the current finding. The specific intervention characteristics required to improve depression remain unclear, however best candidates given current evidence may include, but are not limited to, supervised, aerobic-based activity of moderate-to-vigorous intensity, engaged in multiple times per week over eight or more weeks. Further research is needed. (Registration: PROSPERO-CRD 42015024388). en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Psychological medicine en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.rights.uri en
dc.subject Humans en
dc.subject Exercise en
dc.subject Exercise Therapy en
dc.subject Depression en
dc.subject Adolescent en
dc.subject Randomized Controlled Trials as Topic en
dc.subject Young Adult en
dc.title Treating depression with physical activity in adolescents and young adults: a systematic review and meta-analysis of randomised controlled trials. en
dc.type Journal Article en
dc.identifier.doi 10.1017/s0033291717002653 en
pubs.issue 7 en
pubs.begin-page 1068 en
pubs.volume 48 en
dc.rights.holder Copyright: Cambridge University Press en
dc.identifier.pmid 28994355 en
pubs.end-page 1083 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Meta-Analysis en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Systematic Review en
pubs.subtype Journal Article en
pubs.elements-id 692265 en Medical and Health Sciences en School of Medicine en Psychological Medicine Dept en
dc.identifier.eissn 1469-8978 en
pubs.record-created-at-source-date 2017-10-11 en
pubs.dimensions-id 28994355 en

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