Molecular Mechanisms Responsible for Increased Vulnerability of the Ageing Oocyte to Oxidative Damage.

Show simple item record Mihalas, Bettina P en Redgrove, Kate A en McLaughlin, Eileen en Nixon, Brett en 2018-11-26T02:12:14Z en 2017-01 en
dc.identifier.citation Oxidative medicine and cellular longevity 2017:4015874 Jan 2017 en
dc.identifier.issn 1942-0900 en
dc.identifier.uri en
dc.description.abstract In their midthirties, women experience a decline in fertility, coupled to a pronounced increase in the risk of aneuploidy, miscarriage, and birth defects. Although the aetiology of such pathologies are complex, a causative relationship between the age-related decline in oocyte quality and oxidative stress (OS) is now well established. What remains less certain are the molecular mechanisms governing the increased vulnerability of the aged oocyte to oxidative damage. In this review, we explore the reduced capacity of the ageing oocyte to mitigate macromolecular damage arising from oxidative insults and highlight the dramatic consequences for oocyte quality and female fertility. Indeed, while oocytes are typically endowed with a comprehensive suite of molecular mechanisms to moderate oxidative damage and thus ensure the fidelity of the germline, there is increasing recognition that the efficacy of such protective mechanisms undergoes an age-related decline. For instance, impaired reactive oxygen species metabolism, decreased DNA repair, reduced sensitivity of the spindle assembly checkpoint, and decreased capacity for protein repair and degradation collectively render the aged oocyte acutely vulnerable to OS and limits their capacity to recover from exposure to such insults. We also highlight the inadequacies of our current armoury of assisted reproductive technologies to combat age-related female infertility, emphasising the need for further research into mechanisms underpinning the functional deterioration of the ageing oocyte. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Oxidative medicine and cellular longevity en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.rights.uri en
dc.subject Oocytes en
dc.subject Mitochondria en
dc.subject Humans en
dc.subject Reactive Oxygen Species en
dc.subject DNA Repair en
dc.subject Oxidative Stress en
dc.subject Aging en
dc.subject Female en
dc.subject M Phase Cell Cycle Checkpoints en
dc.subject Glycation End Products, Advanced en
dc.title Molecular Mechanisms Responsible for Increased Vulnerability of the Ageing Oocyte to Oxidative Damage. en
dc.type Journal Article en
dc.identifier.doi 10.1155/2017/4015874 en
pubs.begin-page 4015874 en
pubs.volume 2017 en
dc.rights.holder Copyright: The authors en
dc.identifier.pmid 29312475 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype review-article en
pubs.subtype Review en
pubs.subtype Journal Article en
pubs.elements-id 705899 en
dc.identifier.eissn 1942-0994 en
pubs.record-created-at-source-date 2018-01-10 en
pubs.dimensions-id 29312475 en

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