Brain Injury Lesion Imaging Using Preconditioned Quantitative Susceptibility Mapping without Skull Stripping.

Show simple item record Soman, S en Liu, Z en Kim, G en Nemec, U en Holdsworth, Samantha en Main, K en Lee, B en Kolakowsky-Hayner, S en Selim, M en Furst, AJ en Massaband, P en Yesavage, J en Adamson, MM en Spincemaille, P en Moseley, M en Wang, Y en 2018-12-02T21:59:14Z en 2018-04 en
dc.identifier.citation AJNR. American journal of neuroradiology 39(4):648-653 Apr 2018 en
dc.identifier.issn 0195-6108 en
dc.identifier.uri en
dc.description.abstract BACKGROUND AND PURPOSE:Identifying cerebral microhemorrhage burden can aid in the diagnosis and management of traumatic brain injury, stroke, hypertension, and cerebral amyloid angiopathy. MR imaging susceptibility-based methods are more sensitive than CT for detecting cerebral microhemorrhage, but methods other than quantitative susceptibility mapping provide results that vary with field strength and TE, require additional phase maps to distinguish blood from calcification, and depict cerebral microhemorrhages as bloom artifacts. Quantitative susceptibility mapping provides universal quantification of tissue magnetic property without these constraints but traditionally requires a mask generated by skull-stripping, which can pose challenges at tissue interphases. We evaluated the preconditioned quantitative susceptibility mapping MR imaging method, which does not require skull-stripping, for improved depiction of brain parenchyma and pathology. MATERIALS AND METHODS:Fifty-six subjects underwent brain MR imaging with a 3D multiecho gradient recalled echo acquisition. Mask-based quantitative susceptibility mapping images were created using a commonly used mask-based quantitative susceptibility mapping method, and preconditioned quantitative susceptibility images were made using precondition-based total field inversion. All images were reviewed by a neuroradiologist and a radiology resident. RESULTS:Ten subjects (18%), all with traumatic brain injury, demonstrated blood products on 3D gradient recalled echo imaging. All lesions were visible on preconditioned quantitative susceptibility mapping, while 6 were not visible on mask-based quantitative susceptibility mapping. Thirty-one subjects (55%) demonstrated brain parenchyma and/or lesions that were visible on preconditioned quantitative susceptibility mapping but not on mask-based quantitative susceptibility mapping. Six subjects (11%) demonstrated pons artifacts on preconditioned quantitative susceptibility mapping and mask-based quantitative susceptibility mapping; they were worse on preconditioned quantitative susceptibility mapping. CONCLUSIONS:Preconditioned quantitative susceptibility mapping MR imaging can bring the benefits of quantitative susceptibility mapping imaging to clinical practice without the limitations of mask-based quantitative susceptibility mapping, especially for evaluating cerebral microhemorrhage-associated pathologies, such as traumatic brain injury. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries AJNR. American journal of neuroradiology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.rights.uri en
dc.subject Skull en
dc.subject Humans en
dc.subject Image Interpretation, Computer-Assisted en
dc.subject Imaging, Three-Dimensional en
dc.subject Magnetic Resonance Imaging en
dc.subject Adult en
dc.subject Middle Aged en
dc.subject Female en
dc.subject Male en
dc.subject Neuroimaging en
dc.subject Brain Injuries, Traumatic en
dc.title Brain Injury Lesion Imaging Using Preconditioned Quantitative Susceptibility Mapping without Skull Stripping. en
dc.type Journal Article en
dc.identifier.doi 10.3174/ajnr.a5550 en
pubs.issue 4 en
pubs.begin-page 648 en
pubs.volume 39 en
dc.rights.holder Copyright: American Journal of Neuroradiology en
dc.identifier.pmid 29472296 en
pubs.end-page 653 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype research-article en
pubs.subtype Journal Article en
pubs.subtype Research Support, N.I.H., Extramural en
pubs.elements-id 726482 en Medical and Health Sciences en Medical Sciences en Anatomy and Medical Imaging en
dc.identifier.eissn 1936-959X en
pubs.record-created-at-source-date 2018-02-24 en
pubs.dimensions-id 29472296 en

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