Glia and hemichannels: key mediators of perinatal encephalopathy.

Show simple item record Galinsky, Robert en Davidson, Joanne en Dean, Justin en Green, Colin en Bennet, Laura en Gunn, Alistair en 2018-12-02T22:28:21Z en 2018-02 en
dc.identifier.citation Neural regeneration research 13(2):181-189 Feb 2018 en
dc.identifier.issn 1673-5374 en
dc.identifier.uri en
dc.description.abstract Perinatal encephalopathy remains a major cause of disability, such as cerebral palsy. Therapeutic hypothermia is now well established to partially reduce risk of disability in late preterm/term infants. However, new and complementary therapeutic targets are needed to further improve outcomes. There is increasing evidence that glia play a key role in neural damage after hypoxia-ischemia and infection/inflammation. In this review, we discuss the role of astrocytic gap junction (connexin) hemichannels in the spread of neural injury after hypoxia-ischemia and/or infection/inflammation. Potential mechanisms of hemichannel mediated injury likely involve impaired intracellular calcium handling, loss of blood-brain barrier integrity and release of adenosine triphosphate (ATP) resulting in over-activation of purinergic receptors. We propose the hypothesis that inflammation-induced opening of connexin hemichannels is a key regulating event that initiates a vicious cycle of excessive ATP release, which in turn propagates activation of purinergic receptors on microglia and astrocytes. This suggests that developing new neuroprotective strategies for preterm infants will benefit from a detailed understanding of glial and connexin hemichannel responses. en
dc.format.medium Print en
dc.language eng en
dc.relation.ispartofseries Neural regeneration research en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.rights.uri en
dc.title Glia and hemichannels: key mediators of perinatal encephalopathy. en
dc.type Journal Article en
dc.identifier.doi 10.4103/1673-5374.226378 en
pubs.issue 2 en
pubs.begin-page 181 en
pubs.volume 13 en
dc.rights.holder Copyright: The author en
dc.identifier.pmid 29557357 en
pubs.end-page 189 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype review-article en
pubs.subtype Review en
pubs.subtype Journal Article en
pubs.elements-id 732851 en Medical and Health Sciences en Medical Sciences en Physiology Division en Science en Science Research en Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1876-7958 en
pubs.record-created-at-source-date 2018-03-21 en
pubs.dimensions-id 29557357 en

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