Micelle directed chemical polymerization of polypyrrole particles for the electrically triggered release of dexamethasone base and dexamethasone phosphate.

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dc.contributor.author Uppalapati, Dedeepya en
dc.contributor.author Sharma, Manisha en
dc.contributor.author Aqrawe, Zaid en
dc.contributor.author Coutinho, Frazer en
dc.contributor.author Rupenthal, Ilva en
dc.contributor.author Boyd, Ben J en
dc.contributor.author Travas-Sejdic, Jadranka en
dc.contributor.author Svirskis, Darren en
dc.date.accessioned 2018-12-02T22:32:21Z en
dc.date.issued 2018-05 en
dc.identifier.issn 0378-5173 en
dc.identifier.uri http://hdl.handle.net/2292/44754 en
dc.description.abstract Conducting polymers such as polypyrrole (PPy) can be used as electrically responsive drug delivery systems typically prepared by electrochemical polymerisation, however, the amount of drug that can be delivered is typically low. To increase drug delivery capacity and prepare larger amounts of polymer, PPy nanoparticles were produced by chemical polymerisation over drug-loaded micelles. Two forms of dexamethasone were included to increase total drug loading and to explore the mechanisms of loading and release. The particles produced were approximately 50 nm in size and their conductivity and reversible redox activity were demonstrated. Loading of the hydrophobic dexamethasone base was more efficient than for the more hydrophilic phosphate salt. After pressing the particles into the desired form, electrically-responsive drug release was achieved with a pulsed potential signal being the most effective way to trigger release. Notably, the anionic phosphate salt of the drug was more sensitive to electrically stimulated release than the uncharged base of dexamethasone, highlighting the role of electrostatic forces in driving drug release. This system has potential to be loaded with different drugs widening the scope of application of these smart particles to treat a range of disease states. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries International journal of pharmaceutics en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Cell Line en
dc.subject Humans en
dc.subject Benzenesulfonates en
dc.subject Pyrroles en
dc.subject Dexamethasone en
dc.subject Polymers en
dc.subject Drug Carriers en
dc.subject Glucocorticoids en
dc.subject Surface-Active Agents en
dc.subject Cell Survival en
dc.subject Micelles en
dc.subject Electrochemistry en
dc.subject Retinal Pigment Epithelium en
dc.subject Electrochemical Techniques en
dc.subject Polymerization en
dc.subject Drug Liberation en
dc.title Micelle directed chemical polymerization of polypyrrole particles for the electrically triggered release of dexamethasone base and dexamethasone phosphate. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.ijpharm.2018.03.039 en
pubs.issue 1-2 en
pubs.begin-page 38 en
pubs.volume 543 en
dc.rights.holder Copyright: The author en
dc.identifier.pmid 29581065 en
pubs.end-page 45 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Journal Article en
pubs.elements-id 734724 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Pharmacy en
pubs.org-id School of Medicine en
pubs.org-id Ophthalmology Department en
pubs.org-id Science en
pubs.org-id Chemistry en
dc.identifier.eissn 1873-3476 en
pubs.record-created-at-source-date 2018-03-28 en
pubs.dimensions-id 29581065 en

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