dc.contributor.author |
Schey, Kevin L |
en |
dc.contributor.author |
Yugova, Rosica |
en |
dc.contributor.author |
Gletten, Romell |
en |
dc.contributor.author |
Donaldson, Paul |
en |
dc.date.accessioned |
2018-12-03T03:23:53Z |
en |
dc.date.issued |
2017-12-12 |
en |
dc.identifier.issn |
1422-0067 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/44792 |
en |
dc.description.abstract |
Abstract: Aquaporins (AQPs), by playing essential roles in the maintenance of ocular lens homeostasis, contribute to the establishment and maintenance of the overall optical properties of the lens over many decades of life. Three aquaporins, AQP0, AQP1 and AQP5, each with distinctly different functional properties, are abundantly and differentially expressed in the different regions of the ocular lens. Furthermore, the diversity of AQP functionality is increased in the absence of protein turnover by age-related modifications to lens AQPs that are proposed to alter AQP function in the different regions of the lens. These regional differences in AQP functionality are proposed to contribute to the generation and directionality of the lens internal microcirculation; a system of circulating ionic and fluid fluxes that delivers nutrients to and removes wastes from the lens faster than could be achieved by passive diffusion alone. In this review, we present how regional differences in lens AQP isoforms potentially contribute to this microcirculation system by highlighting current areas of investigation and emphasizing areas where future work is required. |
en |
dc.format.medium |
Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
International journal of molecular sciences |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1661-6596/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
http://creativecommons.org/licenses/by/4.0/ |
en |
dc.subject |
Lens, Crystalline |
en |
dc.subject |
Animals |
en |
dc.subject |
Humans |
en |
dc.subject |
Water |
en |
dc.subject |
Aquaporins |
en |
dc.subject |
Eye Proteins |
en |
dc.subject |
Protein Isoforms |
en |
dc.subject |
Biological Transport, Active |
en |
dc.subject |
Homeostasis |
en |
dc.subject |
Permeability |
en |
dc.title |
The Role of Aquaporins in Ocular Lens Homeostasis. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.3390/ijms18122693 |
en |
pubs.issue |
12 |
en |
pubs.volume |
18 |
en |
dc.rights.holder |
Copyright: The authors |
en |
dc.identifier.pmid |
29231874 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
review-article |
en |
pubs.subtype |
Review |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
719696 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Physiology Division |
en |
dc.identifier.eissn |
1422-0067 |
en |
pubs.record-created-at-source-date |
2017-12-13 |
en |
pubs.dimensions-id |
29231874 |
en |