dc.contributor.author |
Stewart, Sarah |
en |
dc.contributor.author |
Rome, Keith |
en |
dc.contributor.author |
Eason, Alastair |
en |
dc.contributor.author |
House, Meaghan |
en |
dc.contributor.author |
Horne, Anne |
en |
dc.contributor.author |
Doyle, Anthony |
en |
dc.contributor.author |
Knight, Julie |
en |
dc.contributor.author |
Taylor, William J |
en |
dc.contributor.author |
Dalbeth, Nicola |
en |
dc.date.accessioned |
2018-12-03T20:56:26Z |
en |
dc.date.issued |
2018-08 |
en |
dc.identifier.issn |
0770-3198 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/44833 |
en |
dc.description.abstract |
The objective of the study was to determine clinical factors associated with activity limitation and predictors of a change in activity limitation after 1 year in people with gout. Two hundred ninety-five participants with gout (disease duration < 10 years) attended a baseline assessment which included medical and disease-specific history, pain visual analog score and plain radiographs scored for erosion and narrowing. Activity limitation was assessed using the Health Assessment Questionnaire-II (HAQ-II). After 1 year, participants were invited to complete a further HAQ-II; follow-up questionnaires were available for 182 participants. Fully saturated and stepwise regression analyses were used to determine associations between baseline characteristics and HAQ-II at baseline and 1 year, and to determine predictors of worsening HAQ-II in those with normal baseline scores. Median (range) baseline HAQ-II was 0.20 (0-2.50) and 0.20 (0-2.80) after 1 year of follow-up. Pain score was the strongest independent predictor of baseline HAQ-II, followed by radiographic narrowing score, type 2 diabetes, swollen joint count, BMI, age and urate (model R2 = 0.51, P < 0.001). Baseline HAQ-II was the strongest predictor of change in HAQ-II at 1 year, followed by tender joint count (model R2 = 0.19, P < 0.001). Of those with HAQ-II scores of 0 at baseline (n = 59, 32% of those with follow-up data), most did not progress (n = 52, 88%); however, baseline pain score, type 2 diabetes and flare frequency were significant predictors of worsening HAQ-II in this group (R2 = 0.34, P < 0.001). People with gout experience a wide range of activity limitation, and levels of activity limitation are, on average, stable over a 1-year period. Baseline pain scores are strongly associated with activity limitation and predict development of activity limitation in those with normal HAQ-II scores at baseline. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Clinical rheumatology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Humans |
en |
dc.subject |
Gout |
en |
dc.subject |
Diabetes Mellitus, Type 2 |
en |
dc.subject |
Disability Evaluation |
en |
dc.subject |
Body Mass Index |
en |
dc.subject |
Activities of Daily Living |
en |
dc.subject |
Health Surveys |
en |
dc.subject |
Severity of Illness Index |
en |
dc.subject |
Prospective Studies |
en |
dc.subject |
Middle Aged |
en |
dc.subject |
New Zealand |
en |
dc.subject |
Female |
en |
dc.subject |
Male |
en |
dc.title |
Predictors of activity limitation in people with gout: a prospective study. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1007/s10067-018-4110-6 |
en |
pubs.issue |
8 |
en |
pubs.begin-page |
2213 |
en |
pubs.volume |
37 |
en |
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
29680870 |
en |
pubs.end-page |
2219 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Journal Article |
en |
pubs.subtype |
Observational Study |
en |
pubs.elements-id |
738492 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Faculty Administration FMHS |
en |
pubs.org-id |
FMHS Research Support |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Anatomy and Medical Imaging |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Medicine Department |
en |
dc.identifier.eissn |
1434-9949 |
en |
pubs.record-created-at-source-date |
2018-04-23 |
en |
pubs.dimensions-id |
29680870 |
en |