dc.contributor.author |
Ruiz-Romeu, Ester |
en |
dc.contributor.author |
Ferran, Marta |
en |
dc.contributor.author |
Giménez-Arnau, Ana |
en |
dc.contributor.author |
Bugara, Beata |
en |
dc.contributor.author |
Lipert, Barbara |
en |
dc.contributor.author |
Jura, Jolanta |
en |
dc.contributor.author |
Florencia, Edwin F |
en |
dc.contributor.author |
Prens, Errol P |
en |
dc.contributor.author |
Celada, Antonio |
en |
dc.contributor.author |
Pujol, Ramon M |
en |
dc.contributor.author |
Santamaria-Babí, Luis F |
en |
dc.date.accessioned |
2018-12-06T00:22:07Z |
en |
dc.date.issued |
2016-08 |
en |
dc.identifier.issn |
0022-202X |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/44878 |
en |
dc.description.abstract |
ZC3H12A, which encodes the RNase monocyte chemotactic protein-induced protein 1 (MCPIP1), is up-regulated in psoriatic skin and reduced to normal levels after clinical treatments with anti-IL-17A/IL-17R neutralizing antibodies. In IL-17A-stimulated keratinocytes, MCPIP1 is rapidly increased at the transcript and protein levels. Also, IL-17A was found to be the main inducer of ZC3H12A expression in keratinocytes treated with supernatants derived from a Streptococcus pyogenes-activated psoriatic ex vivo model based on the co-culture of psoriatic cutaneous lymphocyte-associated antigen (CLA(+)) T cells and lesional epidermal cells. Moreover, MCPIP1 was aberrantly distributed in the suprabasal layers of psoriatic epidermis. In psoriatic samples, IL-17A-stimulated epidermal cell suspensions showed an increased MCPIP1 expression, especially in the mid-differentiated cellular compartment. The knockdown of ZC3H12A showed that this RNase participates in the regulation of the mRNAs present in suprabasal differentiated keratinocytes. Furthermore, JAK/STAT3 inhibition prevented the IL-17A-dependent induction of MCPIP1. In the mouse model of imiquimod-induced psoriasis, Zc3h12a expression was abrogated in Il17ra(-/-) mice. These results support the notion that IL-17A-mediated induction of MCPIP1 is involved in the regulation of local altered gene expression in suprabasal epidermal layers in psoriasis. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
The Journal of investigative dermatology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Epidermis |
en |
dc.subject |
Keratinocytes |
en |
dc.subject |
Skin |
en |
dc.subject |
Animals |
en |
dc.subject |
Mice, Inbred BALB C |
en |
dc.subject |
Mice, Knockout |
en |
dc.subject |
Humans |
en |
dc.subject |
Mice |
en |
dc.subject |
Psoriasis |
en |
dc.subject |
Inflammation |
en |
dc.subject |
Aminoquinolines |
en |
dc.subject |
Ribonucleases |
en |
dc.subject |
Tumor Necrosis Factor-alpha |
en |
dc.subject |
Membrane Glycoproteins |
en |
dc.subject |
Transcription Factors |
en |
dc.subject |
Antigens, Differentiation, T-Lymphocyte |
en |
dc.subject |
Interleukin-17 |
en |
dc.subject |
Biopsy |
en |
dc.subject |
Coculture Techniques |
en |
dc.subject |
Gene Silencing |
en |
dc.subject |
Phosphorylation |
en |
dc.subject |
STAT3 Transcription Factor |
en |
dc.subject |
Receptors, Interleukin-17 |
en |
dc.title |
MCPIP1 RNase Is Aberrantly Distributed in Psoriatic Epidermis and Rapidly Induced by IL-17A. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.jid.2016.04.030 |
en |
pubs.issue |
8 |
en |
pubs.begin-page |
1599 |
en |
pubs.volume |
136 |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.end-page |
1607 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
741946 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Auckland Cancer Research |
en |
dc.identifier.eissn |
1523-1747 |
en |
pubs.record-created-at-source-date |
2016-05-16 |
en |
pubs.dimensions-id |
27180111 |
en |