MCR-1: a promising target for structure-based design of inhibitors to tackle polymyxin resistance.

Son, Soo; Huang, Renjie; Squire, Christopher; Leung, Ka Ho Ivanhoe

dc.contributor.author	Son, Soo	en
dc.contributor.author	Huang, Renjie	en
dc.contributor.author	Squire, Christopher	en
dc.contributor.author	Leung, Ka Ho Ivanhoe	en
dc.date.accessioned	2018-12-06T02:02:09Z	en
dc.date.issued	2019-01	en
dc.identifier.citation	Drug discovery today 24(1):206-216 Jan 2019	en
dc.identifier.issn	1359-6446	en
dc.identifier.uri	http://hdl.handle.net/2292/44893	en
dc.description.abstract	The spread of a novel mobile colistin resistance gene (mcr1) has jeopardised the use of polymyxins, last-resort antibiotics that are used increasingly to treat infections caused by multidrug-resistant (MDR) Gram-negative pathogens. In early 2017, the WHO reported the global spread of mcr1 within a few years after its initial discovery in China. The protein encoded by mcr1 is a putative 60-kDa phosphoethanolamine (pEtN) transferase, MCR-1, and has been studied extensively since its discovery. Herein, we present a comprehensive review of MCR-1 covering its structure, function, and mechanism, to call for the rational drug design of molecular inhibitors of MCR-1 to use in colistin-based combination therapies.	en
dc.format.medium	Print-Electronic	en
dc.language	eng	en
dc.relation.ispartofseries	Drug discovery today	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0	en
dc.subject	Bacteria	en
dc.subject	Polymyxins	en
dc.subject	Transferases	en
dc.subject	Escherichia coli Proteins	en
dc.subject	Anti-Bacterial Agents	en
dc.subject	Microbial Sensitivity Tests	en
dc.subject	Drug Resistance, Bacterial	en
dc.subject	Protein Conformation	en
dc.title	MCR-1: a promising target for structure-based design of inhibitors to tackle polymyxin resistance.	en
dc.type	Journal Article	en
dc.identifier.doi	10.1016/j.drudis.2018.07.004	en
pubs.issue	1	en
pubs.begin-page	206	en
pubs.volume	24	en
dc.rights.holder	Copyright: Elsevier	en
pubs.end-page	216	en
pubs.publication-status	Published	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/OpenAccess	en
pubs.subtype	Research Support, Non-U.S. Gov't	en
pubs.subtype	Review	en
pubs.subtype	Journal Article	en
pubs.elements-id	750413	en
pubs.org-id	Science	en
pubs.org-id	Biological Sciences	en
pubs.org-id	Chemistry	en
pubs.org-id	Science Research	en
pubs.org-id	Maurice Wilkins Centre (2010-2014)	en
dc.identifier.eissn	1878-5832	en
pubs.record-created-at-source-date	2018-07-24	en
pubs.dimensions-id	30036574	en