The relationship between ferritin and urate levels and risk of gout.

Show simple item record Fatima, Tahzeeb en McKinney, Cushla en Major, Tanya J en Stamp, Lisa K en Dalbeth, Nicola en Iverson, Cory en Merriman, Tony R en Miner, Jeffrey N en 2018-12-09T22:49:41Z en 2018-08-15 en
dc.identifier.issn 1478-6354 en
dc.identifier.uri en
dc.description.abstract BACKGROUND:Ferritin positively associates with serum urate and an interventional study suggests that iron has a role in triggering gout flares. The objective of this study was to further explore the relationship between iron/ferritin and urate/gout. METHODS:European (100 cases, 60 controls) and Polynesian (100 cases, 60 controls) New Zealand (NZ) males and 189 US male cases and 60 male controls participated. The 10,727 participants without gout were from the Jackson Heart (JHS; African American = 1260) and NHANES III (European = 5112; African American = 4355) studies. Regression analyses were adjusted for age, sex, body mass index and C-reactive protein. To test for a causal relationship between ferritin and urate, bidirectional two-sample Mendelian randomization analysis was performed. RESULTS:Serum ferritin positively associated with gout in NZ Polynesian (OR (per 10 ng ml- 1 increase) = 1.03, p = 1.8E-03) and US (OR = 1.11, p = 7.4E-06) data sets but not in NZ European (OR = 1.00, p = 0.84) data sets. Ferritin positively associated with urate in NZ Polynesian (β (mg dl- 1) = 0.014, p = 2.5E-04), JHS (β = 0.009, p = 3.2E-05) and NHANES III (European β = 0.007, p = 5.1E-11; African American β = 0.011, p = 2.1E-16) data sets but not in NZ European (β = 0.009, p = 0.31) or US (β = 0.041, p = 0.15) gout data sets. Ferritin positively associated with the frequency of gout flares in two of the gout data sets. By Mendelian randomization analysis a one standard deviation unit increase in iron and ferritin was, respectively, associated with 0.11 (p = 8E-04) and 0.19 mg dl- 1 (p = 2E-04) increases in serum urate. There was no evidence for a causal effect of urate on iron/ferritin. CONCLUSIONS:These data replicate the association of ferritin with serum urate. Increased ferritin levels associated with gout and flare frequency. There was evidence of a causal effect of iron and ferritin on urate. en
dc.format.medium Electronic en
dc.language eng en
dc.relation.ispartofseries Arthritis research & therapy en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
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dc.subject Humans en
dc.subject Gout en
dc.subject Uric Acid en
dc.subject Nutrition Surveys en
dc.subject Middle Aged en
dc.subject African Americans en
dc.subject European Continental Ancestry Group en
dc.subject Oceanic Ancestry Group en
dc.subject New Zealand en
dc.subject Female en
dc.subject Male en
dc.subject Ferritins en
dc.title The relationship between ferritin and urate levels and risk of gout. en
dc.type Journal Article en
dc.identifier.doi 10.1186/s13075-018-1668-y en
pubs.issue 1 en
pubs.begin-page 179 en
pubs.volume 20 en
dc.rights.holder Copyright: The author en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype research-article en
pubs.subtype Journal Article en
pubs.elements-id 752861 en Medical and Health Sciences en School of Medicine en Medicine Department en
dc.identifier.eissn 1478-6362 en
pubs.record-created-at-source-date 2018-08-17 en
pubs.dimensions-id 30111358 en

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