Foot and ankle characteristics in systemic lupus erythematosus: A systematic review and meta-analysis.

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Show simple item record Stewart, Sarah en Brenton-Rule, Angela en Dalbeth, Nicola en Aiyer, Ashok en Frampton, Christopher en Rome, Keith en 2018-12-10T00:33:37Z en 2019-04 en
dc.identifier.issn 0049-0172 en
dc.identifier.uri en
dc.description.abstract OBJECTIVE:To determine characteristics of the foot and ankle in people with systemic lupus erythematosus (SLE). METHODS:Medline, CINAHL, Sports-Discus, Scopus and Cochrane Library databases were searched up to January 2018. Studies reporting foot- and ankle-related outcomes in the following domains were included: vascular, neurological, musculoskeletal, cutaneous (skin and nail) or pain/function. The Quality Index tool was used to assess methodological quality. Where appropriate, odds ratio (OR) and mean difference meta-analyses were conducted for case-control studies; and pooled mean prevalence meta-analyses for studies assessing characteristics in SLE. RESULTS:Forty-nine studies were included with mean (range) quality scores of 75% (38-100%). Twenty-three studies assessed vascular characteristics, followed by musculoskeletal (n = 16), neurological (n = 11), cutaneous (n = 5) and pain/function (n = 4). Foot and ankle characteristics in people with SLE included impaired vascular supply, abnormal nerve function, musculoskeletal pathology, skin and nail pathology, and pain and functional disability. Twenty-four studies were included in meta-analyses. Pooled OR for abnormal ankle brachial index was 3.08 for SLE compared with controls. Pooled mean difference in brachial-ankle pulse-wave velocity between SLE and controls was significant (161.39 cm/s, P = 0.004). Pooled prevalence was 0.54 for intermittent claudication, 0.50 for Raynaud's phenomenon, 0.28 for chilblains, 0.00 for gangrene, 0.30 for hallux valgus, 0.15 for onychomycosis, 0.76 for history of foot pain, and 0.36 for current foot pain. CONCLUSION:People with SLE experience a wide range of foot and ankle manifestations. Published research highlights the impact of peripheral arterial disease, peripheral neuropathy, musculoskeletal deformity, skin and nail pathology and patient-reported foot pain and disability. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Seminars in arthritis and rheumatism en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject Foot Joints en
dc.subject Humans en
dc.subject Foot Diseases en
dc.subject Pain en
dc.subject Lupus Erythematosus, Systemic en
dc.subject Case-Control Studies en
dc.subject Female en
dc.subject Male en
dc.title Foot and ankle characteristics in systemic lupus erythematosus: A systematic review and meta-analysis. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.semarthrit.2018.07.002 en
pubs.issue 5 en
pubs.begin-page 847 en
pubs.volume 48 en
dc.rights.holder Copyright: The author en
pubs.end-page 859 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Meta-Analysis en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Systematic Review en
pubs.subtype Journal Article en
pubs.elements-id 752862 en Medical and Health Sciences en School of Medicine en Medicine Department en
dc.identifier.eissn 1532-866X en
pubs.record-created-at-source-date 2018-08-11 en
pubs.dimensions-id 30093237 en

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