High Magnesium Corrosion Rate has an Effect on Osteoclast and Mesenchymal Stem Cell Role During Bone Remodelling.

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dc.contributor.author Maradze, Diana en
dc.contributor.author Musson, David en
dc.contributor.author Zheng, Yufeng en
dc.contributor.author Cornish, Jillian en
dc.contributor.author Lewis, Mark en
dc.contributor.author Liu, Yang en
dc.date.accessioned 2018-12-10T02:27:05Z en
dc.date.issued 2018-07-03 en
dc.identifier.citation Scientific reports 8(1):10003 03 Jul 2018 en
dc.identifier.issn 2045-2322 en
dc.identifier.uri http://hdl.handle.net/2292/44972 en
dc.description.abstract The aim of this study was to gain an understanding on the collective cellular effects of magnesium (Mg) corrosion products on the behaviour of cells responsible for bone formation and remodelling. The response of mesenchymal stem cells (MSCs) and osteoclast cells to both soluble (Mg ions) and insoluble (granule) corrosion products were recapitulated in vitro by controlling the concentration of the corrosion products. Clearance of corrosion granules by MSCs was also inspected by TEM analysis at sub-cellular level. The effect of Mg corrosion products varied depending on the state of differentiation of cells, concentration and length of exposure. The presence of the corrosion products significantly altered the cells' metabolic and proliferative activities, which further affected cell fusion/differentiation. While cells tolerated higher than physiological range of Mg concentration (16 mM), concentrations below 10 mM were beneficial for cell growth. Furthermore, MSCs were shown to contribute to the clearance of intercellular corrosion granules, whilst high concentrations of corrosion products negatively impacted on osteoclast progenitor cell number and mature osteoclast cell function. en
dc.format.medium Electronic en
dc.language eng en
dc.relation.ispartofseries Scientific reports en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Osteoclasts en
dc.subject Mesenchymal Stem Cells en
dc.subject Animals en
dc.subject Humans en
dc.subject Mice en
dc.subject Ions en
dc.subject Magnesium en
dc.subject Bone Remodeling en
dc.subject Cell Communication en
dc.subject Cell Differentiation en
dc.subject Cell Proliferation en
dc.subject Osteogenesis en
dc.subject Corrosion en
dc.subject RAW 264.7 Cells en
dc.title High Magnesium Corrosion Rate has an Effect on Osteoclast and Mesenchymal Stem Cell Role During Bone Remodelling. en
dc.type Journal Article en
dc.identifier.doi 10.1038/s41598-018-28476-w en
pubs.issue 1 en
pubs.begin-page 10003 en
pubs.volume 8 en
dc.rights.holder Copyright: The authors en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype research-article en
pubs.subtype Journal Article en
pubs.elements-id 747224 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Medicine Department en
pubs.org-id Science en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 2045-2322 en
pubs.record-created-at-source-date 2018-07-04 en
pubs.dimensions-id 29968794 en

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https://creativecommons.org/licenses/by/4.0/ Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/


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