The Effect of MitoQ on Aging-Related Biomarkers: A Systematic Review and Meta-Analysis

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dc.contributor.author Braakhuis, Andrea en
dc.contributor.author Nagulan,, R en
dc.contributor.author Somerville, Vaughan en
dc.date.accessioned 2018-12-10T20:14:54Z en
dc.date.issued 2018-07-12 en
dc.identifier.citation Oxidative medicine and cellular longevity 2018:8575263 2018 en
dc.identifier.issn 1942-0900 en
dc.identifier.uri http://hdl.handle.net/2292/44987 en
dc.description.abstract Mitochondria are metabolically active organelles that produce significant reactive oxygen species, linked with aging and degenerative diseases. In recent years, particular focus has been put on mitochondria-targeted antioxidants, to decrease the concentration of reactive oxygen species and help alleviate the accumulation of oxidative damage and associated aging. MitoQ is a mitochondria-targeted antioxidant of which is reported to support healthy aging. The aim of this systematic review is to investigate the effects of MitoQ on oxidative outcomes related to the aging process. A predeveloped search strategy was run against MEDLINE (Ovid), EMBASE (Ovid), and CINAHL databases, which identified 10,255 articles of interest, with 27 of these finalised for use after screening. Three outcomes had sufficient data to meta-analyse nitrotyrosine concentration (190 animals, SMD −0.67, 95% CI (−1.30, −0.05), ), membrane potential (63 animals, MD 11.44, 95% CI (1.28–21.60), ), and protein carbonyl concentration (182 animals, SMD −0.13, 95% CI (−0.44, 0.18), ). MitoQ intervention produced a statistically significant reduction in nitrotyrosine concentration and increased membrane potential. MitoQ may be of some benefit in alleviating oxidative stress related to aging. en
dc.publisher Hindawi Publishing Corporation en
dc.relation.ispartofseries Oxidative Medicine and Cellular Longevity en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.title The Effect of MitoQ on Aging-Related Biomarkers: A Systematic Review and Meta-Analysis en
dc.type Journal Article en
dc.identifier.doi 10.1155/2018/8575263 en
dc.rights.holder Copyright: The authors en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Review en
pubs.elements-id 750607 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Nutrition en
pubs.number 8575263 en
pubs.record-created-at-source-date 2018-08-01 en
pubs.dimensions-id 30116495 en


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