dc.contributor.author |
Purohit, Trusha |
en |
dc.contributor.author |
Hanning, Sara |
en |
dc.contributor.author |
Wu, Zimei |
en |
dc.date.accessioned |
2019-02-26T22:16:22Z |
en |
dc.date.issued |
2018-12 |
en |
dc.identifier.issn |
1083-7450 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/45353 |
en |
dc.description.abstract |
Drug delivery via the rectum is a useful alternative route of administration to the oral route for patients who cannot swallow. Traditional rectal dosage forms have been historically used for localized treatments including delivery of laxatives, treatment of hemorrhoids and for delivery of antipyretics. However, the recent trend is showing an increase in the development of novel rectal delivery systems to deliver drug directly into the systemic circulation by taking advantage of porto-systemic shunting. The present review is based on research studies carried out between years 1969-2017. Data for this review have been derived from keyword searches using Scopus and Medline databases. Novel rectal drug delivery systems including hollow-type suppositories, thermo-responsive and muco-adhesive liquid suppositories, and nanoparticulate systems incorporated into an appropriate vehicle have offered more control over delivery of drug molecules for local or systemic actions. In addition, various methods for in vitro-in vivo evaluation of rectal drug delivery systems are covered which is as important as the formulation, and must be carried out using appropriate methodology. Continuous research and development in this field of drug delivery may unleash the hidden potential of the rectal drug delivery systems. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Pharmaceutical development and technology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Rectum |
en |
dc.subject |
Animals |
en |
dc.subject |
Humans |
en |
dc.subject |
Suppositories |
en |
dc.subject |
Excipients |
en |
dc.subject |
Drug Delivery Systems |
en |
dc.subject |
Drug Compounding |
en |
dc.subject |
Drug Liberation |
en |
dc.title |
Advances in rectal drug delivery systems. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1080/10837450.2018.1484766 |
en |
pubs.issue |
10 |
en |
pubs.begin-page |
942 |
en |
pubs.volume |
23 |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.end-page |
952 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Review |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
747226 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Pharmacy |
en |
dc.identifier.eissn |
1097-9867 |
en |
pubs.record-created-at-source-date |
2018-06-12 |
en |
pubs.dimensions-id |
29888992 |
en |