The Influence of Selection on MHC DQA and DQB Haplotypes in the Endemic New Zealand Hector's and Māui Dolphins.

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Show simple item record Heimeier, Dorothea en Alexander, Alana en Hamner, Rebecca M en Pichler, Franz en Baker, Charles en 2019-02-28T21:50:59Z en 2018-10 en
dc.identifier.issn 0022-1503 en
dc.identifier.uri en
dc.description.abstract Strong balancing selection on the major histocompatibility complex (MHC) can lead to different patterns in gene frequencies and neutral genomic variation within species. We investigated diversity and geographic structure of MHC genes DQA and DQB, as well as their inferred functional haplotypes, from 2 regional populations (East and West Coast) of the endangered Hector's dolphin (Cephalorhynchus hectori hectori) and the critically endangered Māui dolphin (Cephalorhynchus hectori maui) (West Coast, North Island), and contrasted these results with patterns from neutral microsatellites. The Māui had the lowest number of alleles for DQA (2) and DQB (3), consistent with strong genetic drift acting on this remnant population. However, the 2 retained DQA alleles are among the most divergent combinations of all 4 alleles found across the Hector's metapopulation, potentially reflecting the retention of divergent alleles due to balancing selection. The high frequency of the divergent DQB*04 allele also gave this population the highest nucleotide diversity for DQB. Strong differentiation was evident for DQA, DQB, and DQA-DQB haplotypes between the regional populations of Hector's dolphins (FST > 0.213) and both subspecies (FST > 0.311). Differentiation was generally greater than observed at neutral microsatellite loci, suggesting the influence of selection between geographically proximate East and West Coast populations. This might be the result of spatial differences in directional selection on those opposite coastlines. In addition, measures of the ratio of nonsynonymous to synonymous substitutions (dN/dS) were consistent with balancing selection over evolutionary time. Together, these results suggest a complex interplay of balancing selection, directional selection, local fidelity, and genetic drift. en
dc.format.medium Print en
dc.language eng en
dc.relation.ispartofseries The Journal of heredity en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject Animals en
dc.subject Dolphins en
dc.subject Genetics, Population en
dc.subject Major Histocompatibility Complex en
dc.subject Haplotypes en
dc.subject Linkage Disequilibrium en
dc.subject Alleles en
dc.subject Hawaii en
dc.subject New Zealand en
dc.subject Selection, Genetic en
dc.subject Phylogeography en
dc.title The Influence of Selection on MHC DQA and DQB Haplotypes in the Endemic New Zealand Hector's and Māui Dolphins. en
dc.type Journal Article en
dc.identifier.doi 10.1093/jhered/esy050 en
pubs.issue 7 en
pubs.begin-page 744 en
pubs.volume 109 en
dc.rights.holder Copyright: The author en
pubs.end-page 756 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Journal Article en
pubs.elements-id 756009 en
dc.identifier.eissn 1465-7333 en
pubs.record-created-at-source-date 2018-09-25 en
pubs.dimensions-id 30247626 en

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