Exercise capacity and cardiac function in adolescents born post-term.

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dc.contributor.author Murali, Mrinal en
dc.contributor.author Hofman, Paul en
dc.contributor.author Behrensdorf Derraik, Jose en
dc.contributor.author Cutfield, Wayne en
dc.contributor.author Hornung, Tim en
dc.contributor.author Gusso, Silmara en
dc.date.accessioned 2019-03-05T02:35:32Z en
dc.date.issued 2018-08-28 en
dc.identifier.citation Scientific reports 8(1):12963 28 Aug 2018 en
dc.identifier.issn 2045-2322 en
dc.identifier.uri http://hdl.handle.net/2292/45744 en
dc.description.abstract There is some evidence that children born post-term (≥42 weeks of gestation) have metabolic abnormalities that may be associated with an increased risk of adverse health outcomes in adulthood. However, there are no data as to whether adolescents born post-term display alterations in aerobic capacity or cardiovascular function. We studied 48 adolescents (56% males) in Auckland (New Zealand) with a mean age of 14.3 years (SD = 1.7): 25 born post-term and 23 born at term (37-41 weeks of gestation). Assessments included metabolic markers in blood, whole body DXA scans, 24-hour ambulatory blood pressure monitoring, maximal exercise capacity, as well as cardiac MRI scan at rest and during submaximal exercise. Exercise capacity was lower in the post-term than in control participants (44.5 vs 47.8 ml/kgffm/min; p = 0.04). There were no differences in left ventricular volumes at rest and during exercise between groups. The 24-hour ambulatory blood pressure monitoring also showed no differences between the two groups. Being born post-term was associated with reduced exercise capacity, but with no observed differences in central cardiac function. We speculate that the reduction in exercise capacity may be due to changes in the peripheral vascular system. en
dc.format.medium Electronic en
dc.language eng en
dc.relation.ispartofseries Scientific reports en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Heart Ventricles en
dc.subject Humans en
dc.subject Magnetic Resonance Imaging en
dc.subject Exercise Test en
dc.subject Blood Pressure en
dc.subject Exercise Tolerance en
dc.subject Adolescent en
dc.subject New Zealand en
dc.subject Female en
dc.subject Male en
dc.title Exercise capacity and cardiac function in adolescents born post-term. en
dc.type Journal Article en
dc.identifier.doi 10.1038/s41598-018-31343-3 en
pubs.issue 1 en
pubs.begin-page 12963 en
pubs.volume 8 en
dc.rights.holder Copyright: The authors en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Clinical Trial en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype research-article en
pubs.subtype Journal Article en
pubs.elements-id 752511 en
pubs.org-id Liggins Institute en
pubs.org-id Science en
pubs.org-id Exercise Sciences en
dc.identifier.eissn 2045-2322 en
pubs.record-created-at-source-date 2018-08-30 en
pubs.dimensions-id 30154437 en


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