dc.contributor.author |
Blanco, PJ |
en |
dc.contributor.author |
Bulant, CA |
en |
dc.contributor.author |
Müller, LO |
en |
dc.contributor.author |
Maso Talou, Gonzalo |
en |
dc.contributor.author |
Bezerra, C Guedes |
en |
dc.contributor.author |
Lemos, PA |
en |
dc.contributor.author |
Feijóo, RA |
en |
dc.date.accessioned |
2019-03-05T02:39:05Z |
en |
dc.date.issued |
2018-11-22 |
en |
dc.identifier.citation |
Scientific reports 8(1):17275 22 Nov 2018 |
en |
dc.identifier.issn |
2045-2322 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/45754 |
en |
dc.description.abstract |
In this work we propose to validate the predictive capabilities of one-dimensional (1D) blood flow models with full three-dimensional (3D) models in the context of patient-specific coronary hemodynamics in hyperemic conditions. Such conditions mimic the state of coronary circulation during the acquisition of the Fractional Flow Reserve (FFR) index. Demonstrating that 1D models accurately reproduce FFR estimates obtained with 3D models has implications in the approach to computationally estimate FFR. To this end, a sample of 20 patients was employed from which 29 3D geometries of arterial trees were constructed, 9 obtained from coronary computed tomography angiography (CCTA) and 20 from intra-vascular ultrasound (IVUS). For each 3D arterial model, a 1D counterpart was generated. The same outflow and inlet pressure boundary conditions were applied to both (3D and 1D) models. In the 1D setting, pressure losses at stenoses and bifurcations were accounted for through specific lumped models. Comparisons between 1D models (FFR1D) and 3D models (FFR3D) were performed in terms of predicted FFR value. Compared to FFR3D, FFR1D resulted with a difference of 0.00 ± 0.03 and overall predictive capability AUC, Acc, Spe, Sen, PPV and NPV of 0.97, 0.98, 0.90, 0.99, 0.82, and 0.99, with an FFR threshold of 0.8. We conclude that inexpensive FFR1D simulations can be reliably used as a surrogate of demanding FFR3D computations. |
en |
dc.format.medium |
Electronic |
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dc.language |
eng |
en |
dc.relation.ispartofseries |
Scientific reports |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
en |
dc.subject |
Humans |
en |
dc.subject |
Coronary Stenosis |
en |
dc.subject |
Imaging, Three-Dimensional |
en |
dc.subject |
Coronary Angiography |
en |
dc.subject |
Ultrasonography, Interventional |
en |
dc.subject |
Models, Cardiovascular |
en |
dc.subject |
Aged |
en |
dc.subject |
Middle Aged |
en |
dc.subject |
Female |
en |
dc.subject |
Male |
en |
dc.subject |
Fractional Flow Reserve, Myocardial |
en |
dc.subject |
Computed Tomography Angiography |
en |
dc.title |
Comparison of 1D and 3D Models for the Estimation of Fractional Flow Reserve. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1038/s41598-018-35344-0 |
en |
pubs.issue |
1 |
en |
pubs.begin-page |
17275 |
en |
pubs.volume |
8 |
en |
dc.rights.holder |
Copyright: The authors |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Comparative Study |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
research-article |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
757163 |
en |
pubs.org-id |
Bioengineering Institute |
en |
dc.identifier.eissn |
2045-2322 |
en |
pubs.record-created-at-source-date |
2018-11-24 |
en |
pubs.dimensions-id |
30467321 |
en |