dc.contributor.author |
Lensen, Sarah |
en |
dc.contributor.author |
Osavlyuk, Diana |
en |
dc.contributor.author |
Armstrong, Sarah |
en |
dc.contributor.author |
Stadelmann, Caroline |
en |
dc.contributor.author |
Hennes, Aurélie |
en |
dc.contributor.author |
Napier, Emma |
en |
dc.contributor.author |
Wilkinson, Jack |
en |
dc.contributor.author |
Sadler, Lynn |
en |
dc.contributor.author |
Gupta, Devashana |
en |
dc.contributor.author |
Strandell, Annika |
en |
dc.contributor.author |
Bergh, Christina |
en |
dc.contributor.author |
Vigneswaran, Kugajeevan |
en |
dc.contributor.author |
Teh, Wan T |
en |
dc.contributor.author |
Hamoda, Haitham |
en |
dc.contributor.author |
Webber, Lisa |
en |
dc.contributor.author |
Wakeman, Sarah A |
en |
dc.contributor.author |
Searle, Leigh |
en |
dc.contributor.author |
Bhide, Priya |
en |
dc.contributor.author |
McDowell, Simon |
en |
dc.contributor.author |
Peeraer, Karen |
en |
dc.contributor.author |
Khalaf, Yacoub |
en |
dc.contributor.author |
Farquhar, Cynthia |
en |
dc.date.accessioned |
2019-03-06T03:51:06Z |
en |
dc.date.issued |
2019-01 |
en |
dc.identifier.citation |
The New England journal of medicine 380(4):325-334 Jan 2019 |
en |
dc.identifier.issn |
0028-4793 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/45791 |
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dc.description.abstract |
BACKGROUND:Endometrial scratching (with the use of a pipelle biopsy) is a technique proposed to facilitate embryo implantation and increase the probability of pregnancy in women undergoing in vitro fertilization (IVF). METHODS:We conducted a pragmatic, multicenter, open-label, randomized, controlled trial. Eligible women were undergoing IVF (fresh-embryo or frozen-embryo transfer), with no recent exposure to disruptive intrauterine instrumentation (e.g., hysteroscopy). Participants were randomly assigned in a 1:1 ratio to either endometrial scratching (by pipelle biopsy between day 3 of the cycle preceding the embryo-transfer cycle and day 3 of the embryo-transfer cycle) or no intervention. The primary outcome was live birth. RESULTS:A total of 1364 women underwent randomization. The frequency of live birth was 180 of 690 women (26.1%) in the endometrial-scratch group and 176 of 674 women (26.1%) in the control group (adjusted odds ratio, 1.00; 95% confidence interval, 0.78 to 1.27). There were no significant between-group differences in the rates of ongoing pregnancy, clinical pregnancy, multiple pregnancy, ectopic pregnancy, or miscarriage. The median score for pain from endometrial scratching (on a scale of 0 to 10, with higher scores indicating worse pain) was 3.5 (interquartile range, 1.9 to 6.0). CONCLUSIONS:Endometrial scratching did not result in a higher rate of live birth than no intervention among women undergoing IVF. (Funded by the University of Auckland and others; PIP Australian New Zealand Clinical Trials Registry number, ACTRN12614000626662 .). |
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dc.format.medium |
Print |
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dc.language |
eng |
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dc.relation.ispartofseries |
The New England journal of medicine |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
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dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.rights.uri |
https://www.nejm.org/author-center/permissions |
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dc.subject |
Endometrium |
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dc.subject |
Humans |
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dc.subject |
Pain Measurement |
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dc.subject |
Treatment Outcome |
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dc.subject |
Embryo Transfer |
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dc.subject |
Fertilization in Vitro |
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dc.subject |
Odds Ratio |
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dc.subject |
Pregnancy |
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dc.subject |
Adult |
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dc.subject |
Female |
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dc.subject |
Live Birth |
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dc.title |
A Randomized Trial of Endometrial Scratching before In Vitro Fertilization. |
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dc.type |
Journal Article |
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dc.identifier.doi |
10.1056/nejmoa1808737 |
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pubs.issue |
4 |
en |
pubs.begin-page |
325 |
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pubs.volume |
380 |
en |
dc.rights.holder |
Copyright: Massachusetts Medical Society |
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pubs.end-page |
334 |
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pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
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pubs.subtype |
Multicenter Study |
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pubs.subtype |
Randomized Controlled Trial |
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pubs.subtype |
Pragmatic Clinical Trial |
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pubs.subtype |
Journal Article |
en |
pubs.elements-id |
761030 |
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pubs.org-id |
Medical and Health Sciences |
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pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Obstetrics and Gynaecology |
en |
dc.identifier.eissn |
1533-4406 |
en |
pubs.record-created-at-source-date |
2019-01-24 |
en |
pubs.dimensions-id |
30673547 |
en |