dc.contributor.author |
Andraos, Stephanie |
en |
dc.contributor.author |
De Seymour, Jamie |
en |
dc.contributor.author |
O'Sullivan, Justin |
en |
dc.contributor.author |
Kussmann, Martin |
en |
dc.date.accessioned |
2019-03-11T20:27:11Z |
en |
dc.date.issued |
2018-12 |
en |
dc.identifier.issn |
1613-4125 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/45893 |
en |
dc.description.abstract |
Epidemiological studies have consistently demonstrated that environmental exposures in early life are associated with later-life health status and disease susceptibility. Epigenetic modifications, such as DNA methylation, have been suggested as potential mechanisms linking the intrauterine environment with offspring health status. The present systematic review compiles peer-reviewed randomized controlled trials assessing the impact of maternal nutritional interventions on DNA methylation patterns of the offspring. The results of the included trials are consistent with micronutrient supplementation not significantly affecting offspring tissue DNA methylation patterns, yet subgrouping by sex, BMI, and smoking status increased the significance of nutritional supplementation on DNA methylation. Maternal BMI and smoking status as well as offspring sex were factors influencing offspring DNA methylation responsiveness to nutritional interventions during pregnancy. Future research should aim at assessing the impact of nutritional interventions on DNA methylation patterns of neonates comparing single versus multi-micronutrient supplementation, within populations having high versus low baseline nutritional statuses. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Molecular nutrition & food research |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Humans |
en |
dc.subject |
Vitamin B 12 |
en |
dc.subject |
Fatty Acids, Omega-3 |
en |
dc.subject |
Micronutrients |
en |
dc.subject |
DNA Methylation |
en |
dc.subject |
Epigenesis, Genetic |
en |
dc.subject |
Nutritional Status |
en |
dc.subject |
Pregnancy |
en |
dc.subject |
Dietary Supplements |
en |
dc.subject |
Infant, Newborn |
en |
dc.subject |
Female |
en |
dc.subject |
Randomized Controlled Trials as Topic |
en |
dc.subject |
Maternal Nutritional Physiological Phenomena |
en |
dc.title |
The Impact of Nutritional Interventions in Pregnant Women on DNA Methylation Patterns of the Offspring: A Systematic Review. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1002/mnfr.201800034 |
en |
pubs.issue |
24 |
en |
pubs.begin-page |
e1800034 |
en |
pubs.volume |
62 |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
Systematic Review |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
753401 |
en |
pubs.org-id |
Academic Services |
en |
pubs.org-id |
Examinations |
en |
pubs.org-id |
Liggins Institute |
en |
dc.identifier.eissn |
1613-4133 |
en |
pubs.record-created-at-source-date |
2018-07-24 |
en |
pubs.dimensions-id |
30035846 |
en |