Repeatability of Arterial Spin Labeling MRI in Measuring Blood Perfusion in the Human Eye.

Show simple item record Khanal, Safal en Turnbull, Philip en Vaghefi Rezaei, Seyed en Phillips, John en 2019-03-11T21:09:22Z en 2019-04 en
dc.identifier.issn 1053-1807 en
dc.identifier.uri en
dc.description.abstract BACKGROUND:Quantifying blood perfusion in ocular tissues is challenging, partly because the majority of the blood is carried by the choroid, which is difficult to visualize because it is located between the retina and sclera. PURPOSE/HYPOTHESIS:To evaluate the intra- and interday repeatability of MRI measures of chorio-retinal blood perfusion. STUDY TYPE:Prospective, cross-sectional, observational study. POPULATION:Twenty young healthy adults (six male, age: 25 ± 5 years) scanned twice within a single session repeated at the same time of day on 2 days. FIELD STRENGTH/SEQUENCE:Arterial spin labeling (ASL) MRI at 3.0T using pseudocontinuous ASL (PCASL) labeling scheme and a 3D turbo-gradient-spin-echo (TGSE) acquisition, including axial T2 -weighted structural images using a 2D turbo-spin-echo (TSE) sequence. ASSESSMENTS:Region-of-interest analysis for assessment of chorio-retinal blood perfusion. STATISTICAL TESTS:Intra- and interday repeatability of measures analyzed using intraclass correlation coefficients (ICC), Pearson's correlation analysis, paired t-tests, and Bland-Altman plots. RESULTS:The mean chorio-retinal perfusion was 77.86 (standard deviation [SD] = 29.80) ml/100ml/min. Perfusion measurements correlated strongly within a single session (r = 0.95, 95% confidence interval [CI] [0.880-0.980], P < 0.001) and between the two sessions based on a single run (r = 0.80 [0.582-0.913], P < 0.001), and two runs (r = 0.80 [0.479-0.918], P < 0.001). There were mean differences of 2.69 [16.85 to -22.23] ml/100ml/min for intraday measures, -7.44 [27.45 to -42.32] ml/100ml/min for single-run interday measures, and 5.73 [28.71 to -40.17] ml/100ml/min for two-run interday measures, but none were significant (all P > 0.05). DATA CONCLUSION:Quantitative ASL-MRI measurements of chorio-retinal blood perfusion showed high intra- and interday repeatability. The ASL-MRI technique provides reliable measures of chorio-retinal perfusion in vivo. LEVEL OF EVIDENCE:1 Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2019;49:966-974. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Journal of magnetic resonance imaging : JMRI en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Repeatability of Arterial Spin Labeling MRI in Measuring Blood Perfusion in the Human Eye. en
dc.type Journal Article en
dc.identifier.doi 10.1002/jmri.26323 en
pubs.issue 4 en
pubs.begin-page 966 en
pubs.volume 49 en
dc.rights.holder Copyright: The author en
pubs.end-page 974 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Journal Article en
pubs.elements-id 753741 en Academic Services en Examinations en Bioengineering Institute en ABI Associates en Medical and Health Sciences en Optometry and Vision Science en
dc.identifier.eissn 1522-2586 en
pubs.record-created-at-source-date 2018-09-26 en
pubs.dimensions-id 30252997 en

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