Effects of Leptin on the Skeleton.

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dc.contributor.author Reid, Ian en
dc.contributor.author Baldock, Paul A en
dc.contributor.author Cornish, Jillian en
dc.date.accessioned 2019-03-19T04:26:06Z en
dc.date.issued 2018-12 en
dc.identifier.issn 0163-769X en
dc.identifier.uri http://hdl.handle.net/2292/46097 en
dc.description.abstract Leptin originates in adipocytes, including those in bone marrow, and circulates in concentrations 20 to 90 times higher than those in the cerebrospinal fluid. It has direct anabolic effects on osteoblasts and chondrocytes, but it also influences bone indirectly, via the hypothalamus and sympathetic nervous system, via changes in body weight, and via effects on the production of other hormones (e.g., pituitary). Leptin's role in bone physiology is determined by the balance of these conflicting effects. Reflecting this inconsistency, the leptin-deficient mouse has reduced length and bone mineral content of long bones but increased vertebral trabecular bone. A consistent bone phenotype in human leptin deficiency has not been established. Systemic leptin administration in animals and humans usually exerts a positive effect on bone mass, and leptin administration into the cerebral ventricles usually normalizes the bone phenotype in leptin-deficient mice. Reflecting the role of the sympathetic nervous system in mediating the central catabolic effects of leptin on the skeleton, β-adrenergic agonists and antagonists have major effects on bone in mice, but this is not consistently seen in humans. The balance of the central and peripheral effects of leptin on bone remains an area of substantial controversy and might vary between species and according to other factors such as body weight, baseline circulating leptin levels, and the presence of specific pathologies. In humans, leptin is likely to contribute to the positive relationship observed between adiposity and bone density, which allows the skeleton to respond appropriately to changes in soft tissue mass. en
dc.format.medium Print en
dc.language eng en
dc.relation.ispartofseries Endocrine reviews en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Bone and Bones en
dc.subject Animals en
dc.subject Humans en
dc.subject Leptin en
dc.subject Bone Density en
dc.subject Adiposity en
dc.title Effects of Leptin on the Skeleton. en
dc.type Journal Article en
dc.identifier.doi 10.1210/er.2017-00226 en
pubs.issue 6 en
pubs.begin-page 938 en
pubs.volume 39 en
dc.rights.holder Copyright: The author en
pubs.end-page 959 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Review en
pubs.subtype Journal Article en
pubs.elements-id 753766 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Medicine Department en
pubs.org-id Science en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1945-7189 en
pubs.record-created-at-source-date 2018-09-06 en
pubs.dimensions-id 30184053 en


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