Distinctive features of polycythaemia vera in New Zealand Polynesians

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dc.contributor.author Hanna, MZ en
dc.contributor.author Kalev, Maggie en
dc.contributor.author Jackson, SR en
dc.contributor.author Royle, G en
dc.contributor.author Blacklock, HA en
dc.date.accessioned 2019-03-21T01:54:16Z en
dc.date.issued 2018-09-21 en
dc.identifier.citation New Zealand Medical Journal 131(1482):38-45 21 Sep 2018 en
dc.identifier.issn 0028-8446 en
dc.identifier.uri http://hdl.handle.net/2292/46247 en
dc.description.abstract AIM:The aim of this study was to examine a potential ethnic disparity in the phenotype of polycythaemia vera (PV) between New Zealand European and Polynesian patients. METHOD:A retrospective review of medical records was conducted at Middlemore Hospital to identify adult patients with PV diagnosed between 1987 and 2007. Data extracted included diagnostic criteria, ethnicity, age, complications and survival. RESULTS:Eighty-eight adult patients with PV were identified during 1987-2007, 49 (55.7%) were Europeans and 36 (40.9%) Polynesians. The most striking finding was that Polynesian patients presented almost 14 years younger than Europeans (mean age of 54 years versus [vs] 68, respectively; P<.001). The white cell and platelet counts were higher in Polynesians compared with Europeans (mean white cell count of 22x109/L vs 13x109/L; mean platelet count of 648x109/L vs 512x109/L, respectively; P<.05 for both). The rate of JAK2 V617F mutation in Polynesians was 96%, equivalent to other large cohorts of European patients. The rates of long-term complications were comparable between Polynesians and Europeans, but the predicted impact on life expectancy was more severe for Polynesians. CONCLUSION:New Zealand Polynesian patients present with a distinctive PV phenotype. Their younger age at presentation suggests a different risk factor profile or a higher genetic susceptibility. We hope our observations initiate larger epidemiological and genetic studies to help elucidate the cause. en
dc.format.medium Electronic en
dc.language eng en
dc.publisher New Zealand Medical Association en
dc.relation.ispartofseries New Zealand Medical Journal en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri http://www.nzma.org.nz/journal/contribute/articles en
dc.subject Humans en
dc.subject Polycythemia Vera en
dc.subject Splenomegaly en
dc.subject Hemoglobins en
dc.subject Leukocyte Count en
dc.subject Platelet Count en
dc.subject Life Expectancy en
dc.subject Retrospective Studies en
dc.subject Follow-Up Studies en
dc.subject Mutation en
dc.subject Adult en
dc.subject Aged en
dc.subject Middle Aged en
dc.subject Oceanic Ancestry Group en
dc.subject New Zealand en
dc.subject Female en
dc.subject Male en
dc.subject Janus Kinase 2 en
dc.subject Leukemia, Myeloid, Acute en
dc.subject Health Status Disparities en
dc.subject Primary Myelofibrosis en
dc.title Distinctive features of polycythaemia vera in New Zealand Polynesians en
dc.type Journal Article en
pubs.issue 1482 en
pubs.begin-page 38 en
pubs.volume 131 en
dc.rights.holder Copyright: NZMA en
pubs.author-url http://www.nzma.org.nz/journal/read-the-journal/all-issues/2010-2019/2018/vol-131-no-1482-21-september-2018/7690 en
pubs.end-page 45 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Article en
pubs.elements-id 754742 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Molecular Medicine en
dc.identifier.eissn 1175-8716 en
pubs.record-created-at-source-date 2019-08-16 en
pubs.dimensions-id 30235191 en

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