dc.contributor.author |
Evans, Stephen |
en |
dc.contributor.author |
Jacobson, Gregory M |
en |
dc.contributor.author |
Goodman, Hugh JB |
en |
dc.contributor.author |
Bird, Steve |
en |
dc.contributor.author |
Jameson, Michael |
en |
dc.date.accessioned |
2019-03-21T20:50:53Z |
en |
dc.date.issued |
2019-06 |
en |
dc.identifier.issn |
0163-4984 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/46262 |
en |
dc.description.abstract |
Selenium (Se) compounds have demonstrated anticancer properties in both preclinical and clinical studies, with particular promise in combination therapy where the optimal form and dose of selenium has yet to be established. In a phase I randomised double-blinded study, the safety, tolerability and pharmacokinetic (PK) profiles of sodium selenite (SS), Se-methylselenocysteine (MSC) and seleno-l-methionine (SLM) were compared in patients with chronic lymphocytic leukaemia and a cohort of patients with solid malignancies. Twenty-four patients received 400 μg of elemental Se as either SS, MSC or SLM for 8 weeks. None of the Se compounds were associated with any significant toxicities, and the total plasma Se AUC of SLM was markedly raised in comparison to MSC and SS. DNA damage assessment revealed negligible genotoxicity, and some minor reductions in lymphocyte counts were observed. At the dose level used, all three Se compounds are well-tolerated and non-genotoxic. Further analyses of the pharmacodynamic effects of Se on healthy and malignant peripheral blood mononuclear cells will inform the future evaluation of higher doses of these Se compounds. The study is registered under the Australian and New Zealand Clinical Trials Registry No: ACTRN12613000118707. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Biological trace element research |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.subject |
Humans |
en |
dc.subject |
DNA Damage |
en |
dc.subject |
Selenium Compounds |
en |
dc.subject |
Selenocysteine |
en |
dc.subject |
Selenomethionine |
en |
dc.subject |
Double-Blind Method |
en |
dc.subject |
Aged |
en |
dc.subject |
Aged, 80 and over |
en |
dc.subject |
Middle Aged |
en |
dc.subject |
Female |
en |
dc.subject |
Male |
en |
dc.subject |
Leukemia, Lymphocytic, Chronic, B-Cell |
en |
dc.title |
Comparative Safety and Pharmacokinetic Evaluation of Three Oral Selenium Compounds in Cancer Patients. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1007/s12011-018-1501-0 |
en |
pubs.issue |
2 |
en |
pubs.begin-page |
395 |
en |
pubs.volume |
189 |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.end-page |
404 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Clinical Trial, Phase I |
en |
pubs.subtype |
Randomized Controlled Trial |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
753363 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Waikato Clinical school |
en |
dc.identifier.eissn |
1559-0720 |
en |
pubs.record-created-at-source-date |
2018-09-07 |
en |
pubs.dimensions-id |
30187284 |
en |