dc.contributor.author |
Guan, Jian |
en |
dc.contributor.author |
Pavlovic, D |
en |
dc.contributor.author |
Dalkie, N |
en |
dc.contributor.author |
Waldvogel, Henry |
en |
dc.contributor.author |
OCarroll, Simon |
en |
dc.contributor.author |
Green, Colin |
en |
dc.contributor.author |
Nicholson, Louise |
en |
dc.date.accessioned |
2019-05-08T02:30:48Z |
en |
dc.date.issued |
2013 |
en |
dc.identifier.citation |
Brain Pathology 23(2):154-164 Mar 2013 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/46436 |
en |
dc.description.abstract |
Vascular degeneration plays a significant role in contributing to neurodegenerative conditions such as Alzheimer's disease. Our understanding of the vascular components in Parkinson's disease is however limited. We have examined the vascular morphology of human brain tissue from both Parkinson's disease and the control cases using immunohistochemical staining and image analysis. The degenerative morphology seen in Parkinson's disease cases included the formation of endothelial cell 'clusters', which may be contributed by the fragmentation of capillaries. When compared to the control cases, the capillaries of Parkinson diseases were less in number (p<0.001), shorter in length (p<0.001) and larger in diameter (p<0.01) with obvious damage to the capillary network evidenced by less branching (p<0.001). The level of degeneration seen in the caudate nucleus was also seen in the age matched control cases. Vessel degeneration associated with Parkinson's disease was, however, found in multiple brain regions, but particularly in the substantia nigra, middle frontal cortex and brainstem nuclei. The data suggest that vascular degeneration could be an additional contributing factor to the progress of Parkinson disease. Thus treatments that prevent vascular degeneration and improve vascular remodeling may be a novel target for the treatment of Parkinson's disease. |
en |
dc.language |
ENG |
en |
dc.publisher |
2012 The Authors; Brain Pathology © 2012 International Society of Neuropathology |
en |
dc.relation.ispartofseries |
Brain Patholy |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Vascular degeneration in Parkinson's Disease. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1111/j.1750-3639.2012.00628.x |
en |
pubs.issue |
2 |
en |
pubs.begin-page |
154 |
en |
pubs.volume |
23 |
en |
dc.identifier.pmid |
22897695 |
en |
pubs.end-page |
164 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
360733 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Anatomy and Medical Imaging |
en |
pubs.org-id |
Pharmacology |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
1750-3639 |
en |
pubs.record-created-at-source-date |
2012-09-03 |
en |
pubs.dimensions-id |
22897695 |
en |