Vertebral strength prediction from Bi-Planar dual energy X-ray absorptiometry under anterior compressive force using a finite element model: An in vitro study

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dc.contributor.author Choisne, Julie en
dc.contributor.author Valiadis, JM en
dc.contributor.author Travert, C en
dc.contributor.author Kolta, S en
dc.contributor.author Roux, C en
dc.contributor.author Skalli, W en
dc.date.accessioned 2019-06-10T01:34:39Z en
dc.date.issued 2018-11 en
dc.identifier.citation Journal of the Mechanical Behavior of Biomedical Materials 87:190-196 Nov 2018 en
dc.identifier.issn 1751-6161 en
dc.identifier.uri http://hdl.handle.net/2292/46885 en
dc.description.abstract Finite element models (FEM) derived from qCT-scans were developed as a clinical tool to evaluate vertebral strength. However, the high dose, time and cost of qCT-scanner are limitations for routine osteoporotic diagnosis. A new approach considers using bi-planar dual energy (BP2E) X-rays absorptiometry to build vertebral FEM using synchronized sagittal and frontal plane radiographs. The purpose of this study was to compare the performance of the areal bone mineral density (aBMD) measured from DXA, qCT-based FEM and BP2E-based FEM in predicting experimental vertebral strength. Twenty eight vertebrae from eleven lumbar spine segments were imaged with qCT, DXA and BP2E X-rays before destructively tested in anterior compression. FEM were built based on qCT and BP2E images for each vertebra. Subject-specific FEM were built based on 1) the BP2E images using 3D reconstruction and volumetric BMD distribution estimation and 2) the qCT scans using slice by slice segmentation and voxel based calibration. Linear regression analysis was performed to find the best predictor for experimental vertebral strength (Fexpe); aBMD, modeled vertebral strength and vertebral stiffness. Areal BMD was moderately correlated with Fexpe (R2 = 0.74). FEM calculations of vertebral strength were highly to strongly correlated with Fexpe (R2 = 0.84, p < 0.001 for BP2E model and R2 = 0.95, p < 0.001 for qCT model). The results of this study suggest that aBMD accounted for only 74% of Fexpe variability while FE models accounted for at least 84%. For anterior compressive loading on isolated vertebral bodies, simplistic loading condition aimed to replicate anterior wedge fractures, both FEM were good predictors of Fexpe. Therefore FEM based on BP2E X-rays absorptiometry could be a good alternative to replace qCT-based models in the prediction of vertebral strength. However future work should investigate the performance of the BP2E-based model in vivo in discriminating patients with and without vertebral fracture in a prospective study. en
dc.publisher Elsevier en
dc.relation.ispartofseries Journal of the Mechanical Behavior of Biomedical Materials en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri https://www.elsevier.com/authors/journal-authors/submit-your-paper/sharing-and-promoting-your-article en
dc.title Vertebral strength prediction from Bi-Planar dual energy X-ray absorptiometry under anterior compressive force using a finite element model: An in vitro study en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.jmbbm.2018.07.026 en
pubs.begin-page 190 en
pubs.volume 87 en
dc.rights.holder Copyright: Elsevier en
pubs.author-url https://www.sciencedirect.com/science/article/pii/S1751616118307690 en
pubs.end-page 196 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 771181 en
pubs.org-id Bioengineering Institute en
dc.identifier.eissn 1878-0180 en
pubs.record-created-at-source-date 2019-05-09 en
pubs.online-publication-date 2018-07-17 en


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