Therapeutic Hypothermia in Neonatal Hypoxic-Ischemic Encephalopathy.

Show simple item record Wassink, Guido en Davidson, Joanne en Dhillon, Simerdeep K en Zhou, Kelly en Bennet, Laura en Thoresen, Marianne en Gunn, Alistair en 2019-06-13T02:12:27Z en 2019-01-14 en
dc.identifier.issn 1528-4042 en
dc.identifier.uri en
dc.description.abstract PURPOSE OF REVIEW:Therapeutic hypothermia reduces death or disability in term and near-term infants with moderate-severe hypoxic-ischemic encephalopathy. Nevertheless, many infants still survive with disability, despite hypothermia, supporting further research in to ways to further improve neurologic outcomes. RECENT FINDINGS:Recent clinical and experimental studies have refined our understanding of the key parameters for hypothermic neuroprotection, including timing of initiation, depth, and duration of hypothermia, and subsequent rewarming rate. However, important knowledge gaps remain. There is encouraging clinical evidence from a small phase II trial that combined treatment of hypothermia with recombinant erythropoietin further reduces risk of disability but definitive studies are still needed. In conclusion, recent studies suggest that current protocols for therapeutic hypothermia are near-optimal, and that the key to better neurodevelopmental outcomes is earlier diagnosis and initiation of hypothermia after birth. Further research is essential to find and evaluate ways to further improve outcomes after hypoxic-ischemic encephalopathy, including add-on therapies for therapeutic hypothermia and preventing pyrexia during labor and delivery. en
dc.format.medium Electronic en
dc.language eng en
dc.relation.ispartofseries Current neurology and neuroscience reports en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject Humans en
dc.subject Hypoxia-Ischemia, Brain en
dc.subject Hypothermia, Induced en
dc.subject Infant en
dc.subject Infant, Newborn en
dc.subject Neuroprotection en
dc.title Therapeutic Hypothermia in Neonatal Hypoxic-Ischemic Encephalopathy. en
dc.type Journal Article en
dc.identifier.doi 10.1007/s11910-019-0916-0 en
pubs.issue 2 en
pubs.begin-page 2 en
pubs.volume 19 en
dc.rights.holder Copyright: The author en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Review en
pubs.subtype Journal Article en
pubs.elements-id 760526 en Medical and Health Sciences en Medical Sciences en Physiology Division en
dc.identifier.eissn 1534-6293 en
pubs.record-created-at-source-date 2019-01-15 en
pubs.dimensions-id 30637551 en

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