dc.contributor.author |
Diesch, Jeannine |
en |
dc.contributor.author |
Bywater, Megan J |
en |
dc.contributor.author |
Sanij, Elaine |
en |
dc.contributor.author |
Cameron, Donald P |
en |
dc.contributor.author |
Schierding, William |
en |
dc.contributor.author |
Brajanovski, Natalie |
en |
dc.contributor.author |
Son, Jinbae |
en |
dc.contributor.author |
Sornkom, Jirawas |
en |
dc.contributor.author |
Hein, Nadine |
en |
dc.contributor.author |
Evers, Maurits |
en |
dc.contributor.author |
Pearson, Richard B |
en |
dc.contributor.author |
McArthur, Grant A |
en |
dc.contributor.author |
Ganley, Austen |
en |
dc.contributor.author |
O'Sullivan, Justin |
en |
dc.contributor.author |
Hannan, Ross D |
en |
dc.contributor.author |
Poortinga, Gretchen |
en |
dc.date.accessioned |
2019-06-13T03:12:54Z |
en |
dc.date.issued |
2019-01-28 |
en |
dc.identifier.citation |
Communications Biology 2:39 28 Jan 2019 |
en |
dc.identifier.issn |
2399-3642 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/47020 |
en |
dc.description.abstract |
The three-dimensional organization of the genome contributes to its maintenance and regulation. While chromosomal regions associate with nucleolar ribosomal RNA genes (rDNA), the biological significance of rDNA-genome interactions and whether they are dynamically regulated during disease remain unclear. rDNA chromatin exists in multiple inactive and active states and their transition is regulated by the RNA polymerase I transcription factor UBTF. Here, using a MYC-driven lymphoma model, we demonstrate that during malignant progression the rDNA chromatin converts to the open state, which is required for tumor cell survival. Moreover, this rDNA transition co-occurs with a reorganization of rDNA-genome contacts which correlate with gene expression changes at associated loci, impacting gene ontologies including B-cell differentiation, cell growth and metabolism. We propose that UBTF-mediated conversion to open rDNA chromatin during malignant transformation contributes to the regulation of specific gene pathways that regulate growth and differentiation through reformed long-range physical interactions with the rDNA. |
en |
dc.format.medium |
Electronic-eCollection |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Communications biology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
en |
dc.subject |
Cell Line, Tumor |
en |
dc.subject |
Chromatin |
en |
dc.subject |
Humans |
en |
dc.subject |
Neoplasms |
en |
dc.subject |
Cell Transformation, Neoplastic |
en |
dc.subject |
Disease Progression |
en |
dc.subject |
Genetic Predisposition to Disease |
en |
dc.subject |
RNA Polymerase II |
en |
dc.subject |
DNA, Ribosomal |
en |
dc.subject |
Gene Expression Profiling |
en |
dc.subject |
Chromatin Assembly and Disassembly |
en |
dc.subject |
Gene Expression Regulation |
en |
dc.subject |
Epistasis, Genetic |
en |
dc.subject |
Genes, rRNA |
en |
dc.subject |
Genome |
en |
dc.title |
Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1038/s42003-019-0284-y |
en |
pubs.begin-page |
39 |
en |
pubs.volume |
2 |
en |
dc.rights.holder |
Copyright: Crown |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
research-article |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
761059 |
en |
pubs.org-id |
Liggins Institute |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Biological Sciences |
en |
dc.identifier.eissn |
2399-3642 |
en |
pubs.record-created-at-source-date |
2019-02-01 |
en |
pubs.dimensions-id |
30701204 |
en |