Practicalities of Total Intravenous Anesthesia and Target-controlled Infusion in Children

Show simple item record Anderson, Brian en Bagshaw, O en 2019-06-18T22:06:55Z en 2019-07-01 en
dc.identifier.issn 0003-3022 en
dc.identifier.uri en
dc.description.abstract Propofol administered in conjunction with an opioid such as remifentanil is used to provide total intravenous anesthesia for children. Drugs can be given as infusion controlled manually by the physician or as automated target-controlled infusion that targets plasma or effect site. Smart pumps programmed with pharmacokinetic parameter estimates administer drugs to a preset plasma concentration. A linking rate constant parameter (keo) allows estimation of effect site concentration. There are two parameter sets, named after the first author describing them, that are commonly used in pediatric target-controlled infusion for propofol (Absalom and Kataria) and one for remifentanil (Minto). Propofol validation studies suggest that these parameter estimates are satisfactory for the majority of children. Recommended target concentrations for both propofol and remifentanil depend on the type of surgery, the degree of surgical stimulation, the use of local anesthetic blocks, and the ventilatory status of the patient. The use of processed electroencephalographic monitoring is helpful in pediatric total intravenous anesthesia and target-controlled infusion anesthesia, particularly in the presence of neuromuscular blockade. en
dc.publisher Lippincott, Williams & Wilkins en
dc.relation.ispartofseries Anesthesiology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Practicalities of Total Intravenous Anesthesia and Target-controlled Infusion in Children en
dc.type Journal Article en
dc.identifier.doi 10.1097/ALN.0000000000002657 en
pubs.issue 1 en
pubs.begin-page 164 en
pubs.volume 131 en
dc.rights.holder Copyright: The author en
pubs.end-page 185 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 769416 en Medical and Health Sciences en School of Medicine en Anaesthesiology en
pubs.record-created-at-source-date 2019-04-27 en 2019-03-25 en
pubs.dimensions-id 30920966 en

Files in this item

There are no files associated with this item.

Find Full text

This item appears in the following Collection(s)

Show simple item record


Search ResearchSpace