Prevalence and discrimination of OMERACT-defined elementary ultrasound lesions of gout in people with asymptomatic hyperuricaemia: A systematic review and meta-analysis.

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dc.contributor.author Stewart, Sarah en
dc.contributor.author Maxwell, Hannah en
dc.contributor.author Dalbeth, Nicola en
dc.date.accessioned 2019-06-18T22:36:40Z en
dc.date.issued 2019-08 en
dc.identifier.issn 0049-0172 en
dc.identifier.uri http://hdl.handle.net/2292/47165 en
dc.description.abstract OBJECTIVES:Ultrasound lesions of gout have been described in people with asymptomatic hyperuricemia. However, the anatomical sites and ultrasound lesions most frequently involved in asymptomatic hyperuricemia have not yet been established. This systematic review and meta-analysis aimed to determine the prevalence of the Outcome Measures in Rheumatology (OMERACT) elementary ultrasound lesions of gout (double contour, aggregates, tophus, erosion) at various sites in people with asymptomatic hyperuricemia and to determine which sites and lesions discriminate from people with normouricemia. METHODS:A systematic search of electronic databases, conference abstracts and reference lists was undertaken. Studies were included if they used ultrasound to image people with asymptomatic hyperuricemia and reported ≥1 OMERACT-defined lesion of gout. Meta-analyses were undertaken for the pooled prevalence of site-specific lesions in people with asymptomatic hyperuricemia, and the pooled odds ratios of these lesions compared to people with normouricemia. RESULTS:Twenty studies were included. The most common site scanned was the first metatarsophalangeal joint (1MTP) (n = 17 studies) and the most common lesion reported, the double contour (n = 18). Meta-analyses of pooled prevalence showed 1MTP double contour was the most frequent finding in people with asymptomatic hyperuricemia (0.31, 95% confidence interval (CI) 0.20-0.42), followed by femoral condyle double contour (0.16, 95%CI 0.08-0.24) and 1MTP tophus (0.16, 95%CI 0.03-0.29). The highest pooled odds ratios for asymptomatic hyperuricemia vs. normouricemia were 6.98 (95%CI 3.14-15.57) for 1MTP double contour, 13.67 (95%CI 5.42-34.49) for femoral condyle double contour and 6.10 (95%CI 1.55-24.04) for 1MTP tophus. CONCLUSION:In people with asymptomatic hyperuricemia, scanning of the 1MTP and femoral condyle for double contour, plus the 1MTP for tophus, has the highest prevalence and discrimination compared to those with normouricemia. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Seminars in arthritis and rheumatism en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Metatarsophalangeal Joint en
dc.subject Humans en
dc.subject Gout en
dc.subject Hyperuricemia en
dc.subject Ultrasonography en
dc.subject Severity of Illness Index en
dc.subject Prevalence en
dc.subject Asymptomatic Diseases en
dc.title Prevalence and discrimination of OMERACT-defined elementary ultrasound lesions of gout in people with asymptomatic hyperuricaemia: A systematic review and meta-analysis. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.semarthrit.2019.01.004 en
pubs.issue 1 en
pubs.begin-page 62 en
pubs.volume 49 en
dc.rights.holder Copyright: The author en
pubs.end-page 73 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Meta-Analysis en
pubs.subtype Systematic Review en
pubs.subtype Journal Article en
pubs.elements-id 761475 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Medicine Department en
dc.identifier.eissn 1532-866X en
pubs.record-created-at-source-date 2019-02-03 en
pubs.dimensions-id 30709689 en


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