dc.contributor.author |
Fan, Dawei |
en |
dc.contributor.author |
Krishnamurthi, Rita |
en |
dc.contributor.author |
Harris, Paul |
en |
dc.contributor.author |
Barber, Peter |
en |
dc.contributor.author |
Guan, Jian |
en |
dc.date.accessioned |
2019-06-18T22:40:51Z |
en |
dc.date.issued |
2019-04 |
en |
dc.identifier.citation |
Annals of clinical and translational neurology 6(4):669-677 Apr 2019 |
en |
dc.identifier.issn |
2328-9503 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/47171 |
en |
dc.description.abstract |
Objective:Many stroke patients make a partial recovery in function during the first 3 months, partially through promoting insulin-like growth factor-1 (IGF-1) function. A prognostic biomarker that associates with IGF-1 function may predict clinical outcome and recovery of stroke. This study evaluated plasma concentrations of IGF-1, IGF binding protein (IGFBP)-3 and cyclic-glycine-proline (cGP) and their associations with clinical outcome in stroke patients. Methods:Thirty-four patients were recruited within 3 days of stroke. Clinical assessments included the National Institutes of Health Stroke Scale (NIHSS) within 3 days (baseline), and at days 7 and 90; the modified Rankin Scale (mRS) and Fugl-Meyer Upper-Limb Assessment Scale (FM-UL) at days 7 and 90. Plasma samples were collected from the patients at the baseline, days 7 and 90. Fifty age-matched control participants with no history of stroke were also recruited and provided plasma samples. IGF-1, IGFBP-3, and cGP concentrations were analyzed using ELISA or HPLC-MS. Results:Baseline concentrations of IGFBP-3, cGP, and cGP/IGF-1 ratio were lower in stroke patients than the control group. The neurological scores of stroke patients were improved and plasma cGP and cGP/IGF-1 ratio increased over time. Baseline cGP/IGF-1 ratio was correlated with the NIHSS scores at day 90 and the changes in NIHSS scores from the baseline to 90 days. Interpretation:Low cGP concentrations and cGP/IGF-1 ratio in stroke patients suggest an impaired IGF-1 function. The cGP/IGF-1 ratio at admission maybe further developed as a prognostic biomarker for stroke recovery. |
en |
dc.format.medium |
Electronic-eCollection |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Annals of clinical and translational neurology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
en |
dc.title |
Plasma cyclic glycine proline/IGF-1 ratio predicts clinical outcome and recovery in stroke patients. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1002/acn3.743 |
en |
pubs.issue |
4 |
en |
pubs.begin-page |
669 |
en |
pubs.volume |
6 |
en |
dc.rights.holder |
Copyright: The authors |
en |
pubs.end-page |
677 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
research-article |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
770167 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Pharmacology |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Medicine Department |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Biological Sciences |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
2328-9503 |
en |
pubs.record-created-at-source-date |
2019-04-26 |
en |
pubs.dimensions-id |
31019991 |
en |