Risk Factors and Attack Rates of Seasonal Influenza Infection: Results of the Southern Hemisphere Influenza and Vaccine Effectiveness Research and Surveillance (SHIVERS) Seroepidemiologic Cohort Study

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dc.contributor.author Huang, QS en
dc.contributor.author Bandaranayake, D en
dc.contributor.author Wood, T en
dc.contributor.author Newbern, EC en
dc.contributor.author Seeds, R en
dc.contributor.author Ralston, J en
dc.contributor.author Waite, B en
dc.contributor.author Bissielo, A en
dc.contributor.author Prasad, Namrata en
dc.contributor.author Todd, A en
dc.contributor.author Jelley, L en
dc.contributor.author Gunn, W en
dc.contributor.author McNicholas, A en
dc.contributor.author Metz, T en
dc.contributor.author Lawrence, S en
dc.contributor.author Collis, E en
dc.contributor.author Retter, A en
dc.contributor.author Wong, S-S en
dc.contributor.author Webby, R en
dc.contributor.author Bocacao, J en
dc.contributor.author Haubrock, J en
dc.contributor.author Mackereth, G en
dc.contributor.author Turner, Nicola en
dc.contributor.author McArdle, Barbara en
dc.contributor.author Cameron, J en
dc.contributor.author Reynolds, EG en
dc.contributor.author Baker, MG en
dc.contributor.author Grant, Cameron en
dc.contributor.author MacArthur, C en
dc.contributor.author Roberts, S en
dc.contributor.author Trenholme, Adrian en
dc.contributor.author Wong, Conroy en
dc.contributor.author Taylor, S en
dc.contributor.author Thomas, P en
dc.contributor.author Duque, Jazmin en
dc.contributor.author Gross, D en
dc.contributor.author Thompson, MG en
dc.contributor.author Widdowson, M-A en
dc.contributor.author Southern Hemisphere Influenza and Vaccine Effectiveness Research and Surveillance (SHIVERS) Investigation Team en
dc.date.accessioned 2019-06-19T21:03:49Z en
dc.date.issued 2019-02-01 en
dc.identifier.citation Journal of Infectious Diseases 219(3):347-357 01 Feb 2019 en
dc.identifier.issn 1537-6613 en
dc.identifier.uri http://hdl.handle.net/2292/47222 en
dc.description.abstract Background:Understanding the attack rate of influenza infection and the proportion who become ill by risk group is key to implementing prevention measures. While population-based studies of antihemagglutinin antibody responses have been described previously, studies examining both antihemagglutinin and antineuraminidase antibodies are lacking. Methods:In 2015, we conducted a seroepidemiologic cohort study of individuals randomly selected from a population in New Zealand. We tested paired sera for hemagglutination inhibition (HAI) or neuraminidase inhibition (NAI) titers for seroconversion. We followed participants weekly and performed influenza polymerase chain reaction (PCR) for those reporting influenza-like illness (ILI). Results:Influenza infection (either HAI or NAI seroconversion) was found in 321 (35% [95% confidence interval, 32%-38%]) of 911 unvaccinated participants, of whom 100 (31%) seroconverted to NAI alone. Young children and Pacific peoples experienced the highest influenza infection attack rates, but overall only a quarter of all infected reported influenza PCR-confirmed ILI, and one-quarter of these sought medical attention. Seroconversion to NAI alone was higher among children aged <5 years vs those aged ≥5 years (14% vs 4%; P < .001) and among those with influenza B vs A(H3N2) virus infections (7% vs 0.3%; P < .001). Conclusions:Measurement of antineuraminidase antibodies in addition to antihemagglutinin antibodies may be important in capturing the true influenza infection rates. en
dc.publisher Oxford University Press (OUP) en
dc.relation.ispartofseries Journal of Infectious Diseases en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of Infectious Diseases following peer review. The version of record Journal of Infectious Diseases 219(3):347-357 01 Feb 2019 is available online at: http://dx.doi.org/10.1093/infdis/jiy443 en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri https://academic.oup.com/journals/pages/access_purchase/rights_and_permissions/self_archiving_policy_b en
dc.title Risk Factors and Attack Rates of Seasonal Influenza Infection: Results of the Southern Hemisphere Influenza and Vaccine Effectiveness Research and Surveillance (SHIVERS) Seroepidemiologic Cohort Study en
dc.type Journal Article en
dc.identifier.doi 10.1093/infdis/jiy443 en
pubs.issue 3 en
pubs.begin-page 347 en
pubs.volume 219 en
dc.rights.holder Copyright: The authors en
pubs.end-page 357 en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Article en
pubs.elements-id 767113 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Medicine Department en
pubs.org-id Paediatrics Child & Youth Hlth en
pubs.record-created-at-source-date 2019-03-29 en
pubs.online-publication-date 2018-07-17 en
pubs.dimensions-id 30016464 en


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