Persistence, Discordance and Diversity of Staphylococcus aureus Nasal and Oropharyngeal Colonization in School-aged Children.

Show simple item record Williamson, Deborah A en Ritchie, Stephen en Keren, Benjamin en Harrington, Michael en Thomas, Mark en Upton, Arlo en Lennon, Diana en Leversha, Alison en 2019-06-19T21:06:59Z en 2016-07 en
dc.identifier.issn 0891-3668 en
dc.identifier.uri en
dc.description.abstract The anterior nares are regarded as the primary site for Staphylococcus aureus colonization, although studies have highlighted the potential importance of colonization at extra-nasal sites, including the oropharynx. Accordingly, the aims of this study were to assess the prevalence, persistence and molecular epidemiology of S. aureus colonization in the nares and oropharynx of Māori and Pacific children, a population with strikingly high rates of S. aureus infection.A cross-sectional study of predominantly Māori and Pacific school-aged children in Auckland, New Zealand was performed in October 2013, and swabs were taken from the nares and oropharynx. Sampling was repeated from the same schools in October 2014. All S. aureus isolates underwent antimicrobial susceptibility testing and spa typing.Overall, 506/893 (56.7%) children were colonized with S. aureus, and the colonization prevalence was significantly higher in the oropharynx than nares (41.1% vs. 31.5%; P < 0.001). Longitudinal colonization was significantly higher in the oropharynx than the nares, and children with longitudinal oropharyngeal colonization were more likely to be colonized with the same spa type than those colonized in the nares (67.6% vs. 37.0%; P = 0.01). Approximately 40% of children had discordant spa types at the nares and oropharynx.Oropharyngeal S. aureus colonization represents a significant reservoir of S. aureus and it is possible that the oropharynx may represent a protected anatomical niche, enabling persistent colonization with the same S. aureus strain. Future study should attempt to better understand the determinants of oropharyngeal carriage. en
dc.format.medium Print en
dc.language eng en
dc.relation.ispartofseries The Pediatric infectious disease journal en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject Nose en
dc.subject Oropharynx en
dc.subject Humans en
dc.subject Staphylococcus aureus en
dc.subject Staphylococcal Infections en
dc.subject Prevalence en
dc.subject Risk Factors en
dc.subject Cross-Sectional Studies en
dc.subject Carrier State en
dc.subject Age Factors en
dc.subject Schools en
dc.subject Adolescent en
dc.subject Child en
dc.subject Child, Preschool en
dc.subject New Zealand en
dc.subject Female en
dc.subject Male en
dc.subject Methicillin-Resistant Staphylococcus aureus en
dc.title Persistence, Discordance and Diversity of Staphylococcus aureus Nasal and Oropharyngeal Colonization in School-aged Children. en
dc.type Journal Article en
dc.identifier.doi 10.1097/inf.0000000000001173 en
pubs.issue 7 en
pubs.begin-page 744 en
pubs.volume 35 en
dc.rights.holder Copyright: The author en
dc.identifier.pmid 27088586 en
pubs.end-page 748 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Journal Article en
pubs.elements-id 526982 en Medical and Health Sciences en Medical Sciences en Molecular Medicine en
dc.identifier.eissn 1532-0987 en
pubs.record-created-at-source-date 2016-06-29 en
pubs.dimensions-id 27088586 en

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