Ethnic differences in nicotine metabolic rate among New Zealanders

Show simple item record Lea, R.A. en Benowitz, N. en Green, M. en Fowles, J. en Vishvanath, A. en Dickson, S. en Lea, M.G. en Woodward, A. en Chambers, G.K. en Phillips, D. en 2009-08-19T04:29:06Z en 2009-08-19T04:29:06Z en 2005 en
dc.identifier.citation New Zealand Medical Journal 118 (1227), 2005 en
dc.identifier.issn 1175-8716 en
dc.identifier.other eid=2-s2.0-29844455835 en
dc.identifier.uri en
dc.description An open access copy of this article is available and complies with the copyright holder/publisher conditions. en
dc.description.abstract Aims: To estimate (a) the prevalence of gene variants associated with slow nicotine metabolism in the general Maori population and (b) nicotine intake and metabolic rate in Maori and European smokers. Methods: The procedure involved (a) genotyping 85 Maori participants for cytochrome P-450 2A6 (CYP2A6) gene variants, which are associated with reduced nicotine metabolic rate (ie CYP2A6*9 and *4); and (b) measuring salivary cotinine (COT) and trans-3?-hydroxycotinine (3-HC) as biomarkers of nicotine intake and metabolic rate in 12 female smokers from the Hawke's Bay Region (6 Maori and 6 European). Results: (a) The frequencies of the slow nicotine metabolising variants, CYP2A6*9 and *4, were significantly higher in Maori compared to European (p<0.01). Indeed, the prevalence of the CYP2A6*9 variant in these Maori was among the highest in the world (?20%). (b) In smokers, the Maori group had ?35% lower 3-HC:COT ratios indicating a reduced metabolic rate, as well a 2-fold lower cotinine levels per cigarette smoked, indicating reduced nicotine intake (p<0.05). The CYP2A6*9 allele was significantly more frequent in Maori smokers (70%) compared to Europeans (30%), p=0.03. Conclusions: The findings of this study provide evidence that Maori are genetically slower nicotine metabolisers compared to Europeans. Although more research is required, this study may help explain, ethnic differences in smoking initiation and may also have important implications for smoking cessation programs - since metabolic differences between groups with varying ancestry implies that different optimal dosages of nicotine replacement therapy may be required for succesful quiting. en
dc.publisher NZMA en
dc.relation.ispartofseries New Zealand Medical Journal en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
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dc.source.uri en
dc.title Ethnic differences in nicotine metabolic rate among New Zealanders en
dc.type Journal Article en
dc.subject.marsden Fields of Research::320000 Medical and Health Sciences en
pubs.issue 1227 en
pubs.volume 118 en
dc.description.version VoR - Version of Record en
dc.rights.holder Copyright: New Zealand Medical Association (NZMA) en
dc.identifier.pmid 16372023 en
dc.rights.accessrights en

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