Drug scavenging lipid based nanoparticles for detoxification in vivo

Abstract

Background and aims of this thesis: Poisoning is a major public health problem. Presently there are few specific antidotes available to treat intoxications. The aim of this thesis was to demonstrate the efficacy of lipid emulsions and particularly liposomes with various different properties to sequester intoxicants and decrease drug toxicity in in vitro and in vivo models. Liposomes which sequester intoxicant in a centre with drug binding activity – pH gradient liposomes which entrap lipophilic weakly acidic/basic intoxicants by ion trapping – and liposomes which sequester intoxicant through electrostatic interaction in the liposome membrane were studied. Intravenous and intraperitoneal routes of administration (Liposome supported peritoneal dialysis (LSPD)) - were also used... Conclusion: Changing site of liposome loading to repurpose liposomes as detoxifying agents is a promising investigational approach. Future investigation may evaluate the effects of liposome based detoxification for both toxic xenobiotics and endogenous toxins.