Concurrent validity of provisional remission criteria for gout: a dual-energy CT study.

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Show simple item record Dalbeth, Nicola en Frampton, Christopher en Fung, Maple en Baumgartner, Scott en Nicolaou, Savvas en Choi, Hyon K en 2019-09-19T01:45:10Z en 2019-06-21 en
dc.identifier.citation Arthritis Research & Therapy 21(1):150 21 Jun 2019 en
dc.identifier.issn 1478-6354 en
dc.identifier.uri en
dc.description.abstract BACKGROUND:Provisional gout remission criteria including five domains (serum urate, tophus, flares, pain due to gout, and patient global assessment) have been proposed. The aim of this study was to test the concurrent validity of the provisional gout remission criteria by comparing the criteria with dual-energy CT (DECT) findings. METHODS:Patients with gout on allopurinol ≥ 300 mg daily were prospectively recruited into a multicenter DECT study. Participants attended a standardized study visit which recorded gout flare frequency in the preceding 12 months, physical examination for tophus, serum urate, and patient questionnaires. DECT scans of both hands/wrists, feet/ankles/Achilles, and knees were analyzed by two DECT radiologists. The relationship between the DECT urate crystal volume and deposition with individual domains as well as the provisional remission criteria set was analyzed. RESULTS:The provisional remission criteria were fulfilled in 23 (15.1%) participants. DECT urate crystal deposition was observed less frequently in those fulfilling the provisional remission criteria (44%), compared with those not fulfilling the criteria (73.6%, odds ratio 0.28, P = 0.004). The median (range) DECT urate crystal volume was 0.00 (0.00-0.46) cm3 for those fulfilling the remission criteria, compared with 0.08 (0.00-19.53) cm3 for those not fulfilling the criteria (P = 0.002). In multivariate regression analysis, the serum urate and tophus domains were most strongly associated with DECT urate crystal deposition. CONCLUSIONS:In people with gout established on allopurinol, a state of remission as defined by the provisional remission criteria is associated with less DECT urate crystal deposition. While this study provides support for the validity of the provisional gout remission criteria, it also demonstrates that some crystal deposition may be present in people achieving these criteria. en
dc.format.medium Electronic en
dc.language eng en
dc.relation.ispartofseries Arthritis research & therapy en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.rights.uri en
dc.subject Joints en
dc.subject Humans en
dc.subject Gout en
dc.subject Uric Acid en
dc.subject Gout Suppressants en
dc.subject Tomography, X-Ray Computed en
dc.subject Remission Induction en
dc.subject Follow-Up Studies en
dc.subject Prospective Studies en
dc.subject Middle Aged en
dc.subject Female en
dc.subject Male en
dc.subject Biomarkers en
dc.title Concurrent validity of provisional remission criteria for gout: a dual-energy CT study. en
dc.type Journal Article en
dc.identifier.doi 10.1186/s13075-019-1941-8 en
pubs.issue 1 en
pubs.begin-page 150 en
pubs.volume 21 en
dc.rights.holder Copyright: The authors en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype research-article en
pubs.subtype Multicenter Study en
pubs.subtype Journal Article en
pubs.elements-id 776482 en Medical and Health Sciences en School of Medicine en Medicine Department en
dc.identifier.eissn 1478-6362 en
pubs.record-created-at-source-date 2019-06-23 en
pubs.dimensions-id 31227018 en

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