Severe Influenza Is Characterized by Prolonged Immune Activation: Results From the SHIVERS Cohort Study.

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dc.contributor.author Wong, Sook-San en
dc.contributor.author Oshansky, Christine M en
dc.contributor.author Guo, Xi-Zhi J en
dc.contributor.author Ralston, Jacqui en
dc.contributor.author Wood, Timothy en
dc.contributor.author Seeds, Ruth en
dc.contributor.author Newbern, Claire en
dc.contributor.author Waite, Ben en
dc.contributor.author Reynolds, Gary en
dc.contributor.author Widdowson, Marc-Alain en
dc.contributor.author Huang, Q Sue en
dc.contributor.author Webby, Richard J en
dc.contributor.author Thomas, Paul G en
dc.contributor.author SHIVERS Investigation Team en
dc.date.accessioned 2019-09-22T21:58:17Z en
dc.date.issued 2018-01 en
dc.identifier.issn 0022-1899 en
dc.identifier.uri http://hdl.handle.net/2292/47882 en
dc.description.abstract Background:The immunologic factors underlying severe influenza are poorly understood. To address this, we compared the immune responses of influenza-confirmed hospitalized individuals with severe acute respiratory illness (SARI) to those of nonhospitalized individuals with influenza-like illness (ILI). Methods:Peripheral blood lymphocytes were collected from 27 patients with ILI and 27 with SARI, at time of enrollment and then 2 weeks later. Innate and adaptive cellular immune responses were assessed by flow cytometry, and serum cytokine levels were assessed by a bead-based assay. Results:During the acute phase, SARI was associated with significantly reduced numbers of circulating myeloid dendritic cells, CD192+ monocytes, and influenza virus-specific CD8+ and CD4+ T cells as compared to ILI. By the convalescent phase, however, most SARI cases displayed continued immune activation characterized by increased numbers of CD16+ monocytes and proliferating, and influenza virus-specific, CD8+ T cells as compared to ILI cases. SARI was also associated with reduced amounts of cytokines that regulate T-cell responses (ie, interleukin 4, interleukin 13, interleukin 12, interleukin 10, and tumor necrosis factor β) and hematopoiesis (interleukin 3 and granulocyte-macrophage colony-stimulating factor) but increased amounts of a proinflammatory cytokine (tumor necrosis factor α), chemotactic cytokines (MDC, MCP-1, GRO, and fractalkine), and growth-promoting cytokines (PDGFBB/AA, VEGF, and EGF) as compared to ILI. Conclusions:Severe influenza cases showed a delay in the peripheral immune activation that likely led prolonged inflammation, compared with mild influenza cases. en
dc.format.medium Print en
dc.language eng en
dc.relation.ispartofseries The Journal of infectious diseases en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject SHIVERS Investigation Team en
dc.subject Dendritic Cells en
dc.subject Lymphocytes en
dc.subject Monocytes en
dc.subject Humans en
dc.subject Inflammation en
dc.subject Cytokines en
dc.subject Cohort Studies en
dc.subject Immunity, Cellular en
dc.subject Adolescent en
dc.subject Adult en
dc.subject Aged en
dc.subject Middle Aged en
dc.subject Child en
dc.subject Female en
dc.subject Male en
dc.subject Influenza, Human en
dc.subject Immunity, Innate en
dc.subject Young Adult en
dc.subject Adaptive Immunity en
dc.title Severe Influenza Is Characterized by Prolonged Immune Activation: Results From the SHIVERS Cohort Study. en
dc.type Journal Article en
dc.identifier.doi 10.1093/infdis/jix571 en
pubs.issue 2 en
pubs.begin-page 245 en
pubs.volume 217 en
dc.rights.holder Copyright: The author en
pubs.end-page 256 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Research Support, U.S. Gov't, P.H.S. en
pubs.subtype research-article en
pubs.subtype Journal Article en
pubs.elements-id 723890 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Paediatrics Child & Youth Hlth en
dc.identifier.eissn 1537-6613 en
pubs.record-created-at-source-date 2017-11-08 en
pubs.dimensions-id 29112724 en


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