dc.contributor.author |
Wong, Sook-San |
en |
dc.contributor.author |
Oshansky, Christine M |
en |
dc.contributor.author |
Guo, Xi-Zhi J |
en |
dc.contributor.author |
Ralston, Jacqui |
en |
dc.contributor.author |
Wood, Timothy |
en |
dc.contributor.author |
Seeds, Ruth |
en |
dc.contributor.author |
Newbern, Claire |
en |
dc.contributor.author |
Waite, Ben |
en |
dc.contributor.author |
Reynolds, Gary |
en |
dc.contributor.author |
Widdowson, Marc-Alain |
en |
dc.contributor.author |
Huang, Q Sue |
en |
dc.contributor.author |
Webby, Richard J |
en |
dc.contributor.author |
Thomas, Paul G |
en |
dc.contributor.author |
SHIVERS Investigation Team |
en |
dc.date.accessioned |
2019-09-22T21:58:17Z |
en |
dc.date.issued |
2018-01 |
en |
dc.identifier.issn |
0022-1899 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/47882 |
en |
dc.description.abstract |
Background:The immunologic factors underlying severe influenza are poorly understood. To address this, we compared the immune responses of influenza-confirmed hospitalized individuals with severe acute respiratory illness (SARI) to those of nonhospitalized individuals with influenza-like illness (ILI). Methods:Peripheral blood lymphocytes were collected from 27 patients with ILI and 27 with SARI, at time of enrollment and then 2 weeks later. Innate and adaptive cellular immune responses were assessed by flow cytometry, and serum cytokine levels were assessed by a bead-based assay. Results:During the acute phase, SARI was associated with significantly reduced numbers of circulating myeloid dendritic cells, CD192+ monocytes, and influenza virus-specific CD8+ and CD4+ T cells as compared to ILI. By the convalescent phase, however, most SARI cases displayed continued immune activation characterized by increased numbers of CD16+ monocytes and proliferating, and influenza virus-specific, CD8+ T cells as compared to ILI cases. SARI was also associated with reduced amounts of cytokines that regulate T-cell responses (ie, interleukin 4, interleukin 13, interleukin 12, interleukin 10, and tumor necrosis factor β) and hematopoiesis (interleukin 3 and granulocyte-macrophage colony-stimulating factor) but increased amounts of a proinflammatory cytokine (tumor necrosis factor α), chemotactic cytokines (MDC, MCP-1, GRO, and fractalkine), and growth-promoting cytokines (PDGFBB/AA, VEGF, and EGF) as compared to ILI. Conclusions:Severe influenza cases showed a delay in the peripheral immune activation that likely led prolonged inflammation, compared with mild influenza cases. |
en |
dc.format.medium |
Print |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
The Journal of infectious diseases |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
SHIVERS Investigation Team |
en |
dc.subject |
Dendritic Cells |
en |
dc.subject |
Lymphocytes |
en |
dc.subject |
Monocytes |
en |
dc.subject |
Humans |
en |
dc.subject |
Inflammation |
en |
dc.subject |
Cytokines |
en |
dc.subject |
Cohort Studies |
en |
dc.subject |
Immunity, Cellular |
en |
dc.subject |
Adolescent |
en |
dc.subject |
Adult |
en |
dc.subject |
Aged |
en |
dc.subject |
Middle Aged |
en |
dc.subject |
Child |
en |
dc.subject |
Female |
en |
dc.subject |
Male |
en |
dc.subject |
Influenza, Human |
en |
dc.subject |
Immunity, Innate |
en |
dc.subject |
Young Adult |
en |
dc.subject |
Adaptive Immunity |
en |
dc.title |
Severe Influenza Is Characterized by Prolonged Immune Activation: Results From the SHIVERS Cohort Study. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1093/infdis/jix571 |
en |
pubs.issue |
2 |
en |
pubs.begin-page |
245 |
en |
pubs.volume |
217 |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.end-page |
256 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, U.S. Gov't, P.H.S. |
en |
pubs.subtype |
research-article |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
723890 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Paediatrics Child & Youth Hlth |
en |
dc.identifier.eissn |
1537-6613 |
en |
pubs.record-created-at-source-date |
2017-11-08 |
en |
pubs.dimensions-id |
29112724 |
en |