dc.contributor.author |
Yokose, Chio |
en |
dc.contributor.author |
Dalbeth, Nicola |
en |
dc.contributor.author |
Wei, Jie |
en |
dc.contributor.author |
Nicolaou, Savvas |
en |
dc.contributor.author |
Simeone, F Joseph |
en |
dc.contributor.author |
Baumgartner, Scott |
en |
dc.contributor.author |
Fung, Maple |
en |
dc.contributor.author |
Zhang, Yuqing |
en |
dc.contributor.author |
Choi, Hyon K |
en |
dc.date.accessioned |
2019-09-23T22:23:23Z |
en |
dc.date.issued |
2020-02 |
en |
dc.identifier.issn |
0049-0172 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/47917 |
en |
dc.description.abstract |
OBJECTIVES:To determine the clustering patterns of monosodium urate (MSU) crystal deposition and bone erosions among patients with gout requiring urate-lowering therapy (ULT) using dual-energy CT (DECT). METHODS:DECT scans of bilateral hands/wrists, feet/ankles, and knees were obtained on 153 patients with gout on allopurinol ≥300 mg daily for ≥3 months. Two radiologists assessed the images at pre-specified sites (15 in the hands/wrists, 12 in the feet/ankles, 4 in the knees). Clustering patterns of MSU crystal deposition and bone erosions were evaluated. RESULTS:Among 153 patients with gout (mean duration, 15 years) on allopurinol (mean duration, 5 years), MSU crystal deposition (67%) affected multiple sites in the hands/wrists, feet/ankles, and knees more often than would be expected by chance (p<0.001 for all 3 regions). In the feet/ankles, bone erosions were also observed in a clustered manner (p<0.001). Presence of MSU crystal deposition at a particular joint was most strongly associated with symmetric involvement of the same joint of the opposite extremity in the hands/wrists, feet/ankles, and knees (adjusted odds ratio (OR) 26.1, 46.9, and 9.9, respectively). Similarly, presence of erosions in the feet/ankles was highly symmetric (adjusted OR 91.4). Erosions were 8-fold more likely to be present in sites with MSU crystal deposition compared to those without. CONCLUSION:Among patients with longstanding gout on ULT, MSU crystal deposition and bone erosions affect multiple joints within the hands/wrists, feet/ankles, and knees in a highly symmetric manner. These radiologic data support the notion of MSU crystal deposition in gout as a symmetric polyarthropathy. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Seminars in arthritis and rheumatism |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Radiologic evidence of symmetric and polyarticular monosodium urate crystal deposition in gout - A cluster pattern analysis of dual-energy CT. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.semarthrit.2019.07.002 |
en |
pubs.issue |
1 |
en |
pubs.begin-page |
54 |
en |
pubs.volume |
50 |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.end-page |
58 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
Journal Article |
en |
pubs.subtype |
Research Support, N.I.H., Extramural |
en |
pubs.elements-id |
779008 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Medicine Department |
en |
dc.identifier.eissn |
1532-866X |
en |
pubs.record-created-at-source-date |
2019-08-03 |
en |
pubs.dimensions-id |
31371194 |
en |