dc.contributor.author |
Weston, Mikail |
en |
dc.contributor.author |
Kaserer, Teresa |
en |
dc.contributor.author |
Wu, Angela |
en |
dc.contributor.author |
Mouravlev, Alexandre |
en |
dc.contributor.author |
Carpenter, Jenna C |
en |
dc.contributor.author |
Snowball, Albert |
en |
dc.contributor.author |
Knauss, Samuel |
en |
dc.contributor.author |
von Schimmelmann, Melanie |
en |
dc.contributor.author |
During, Matthew J |
en |
dc.contributor.author |
Lignani, Gabriele |
en |
dc.contributor.author |
Schorge, Stephanie |
en |
dc.contributor.author |
Young, Deborah |
en |
dc.contributor.author |
Kullmann, Dimitri M |
en |
dc.contributor.author |
Lieb, Andreas |
en |
dc.date.accessioned |
2019-09-23T23:03:36Z |
en |
dc.date.issued |
2019-04-17 |
en |
dc.identifier.citation |
Science advances 5(4):eaaw1567 17 Apr 2019 |
en |
dc.identifier.issn |
2375-2548 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/47924 |
en |
dc.description.abstract |
Designer receptors exclusively activated by designer drugs (DREADDs) derived from muscarinic receptors not only are a powerful tool to test causality in basic neuroscience but also are potentially amenable to clinical translation. A major obstacle, however, is that the widely used agonist clozapine N-oxide undergoes conversion to clozapine, which penetrates the blood-brain barrier but has an unfavorable side effect profile. Perlapine has been reported to activate DREADDs at nanomolar concentrations but is not approved for use in humans by the Food and Drug Administration or the European Medicines Agency, limiting its translational potential. Here, we report that the atypical antipsychotic drug olanzapine, widely available in various formulations, is a potent agonist of the human M4 muscarinic receptor-based DREADD, facilitating clinical translation of chemogenetics to treat central nervous system diseases. |
en |
dc.format.medium |
Electronic-eCollection |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Science advances |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
en |
dc.subject |
Humans |
en |
dc.subject |
Receptor, Muscarinic M4 |
en |
dc.subject |
Serotonin Uptake Inhibitors |
en |
dc.subject |
Designer Drugs |
en |
dc.subject |
Signal Transduction |
en |
dc.subject |
Computer Simulation |
en |
dc.subject |
High-Throughput Screening Assays |
en |
dc.subject |
Olanzapine |
en |
dc.title |
Olanzapine: A potent agonist at the hM4D(Gi) DREADD amenable to clinical translation of chemogenetics. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1126/sciadv.aaw1567 |
en |
pubs.issue |
4 |
en |
pubs.begin-page |
eaaw1567 |
en |
pubs.volume |
5 |
en |
dc.rights.holder |
Copyright: The authors |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
research-article |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
769955 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Pharmacology |
en |
dc.identifier.eissn |
2375-2548 |
en |
pubs.record-created-at-source-date |
2019-04-20 |
en |
pubs.dimensions-id |
31001591 |
en |