The sinonasal mycobiota in chronic rhinosinusitis and control patients.

Show simple item record Hoggard, M en Zoing, M en Biswas, Kristi en Taylor, Michael en Douglas, Richard en 2019-09-25T21:42:19Z en 2019-06 en
dc.identifier.issn 0300-0729 en
dc.identifier.uri en
dc.description.abstract BACKGROUND:While bacterial associations with chronic rhinosinusitis (CRS) are increasingly well described, fewer studies have examined the fungal component of the sinonasal microbiota. Here we present a study of the sinonasal mycobiota in a cohort of 144 patients (106 patients with CRS and 38 controls). METHODOLOGY:Fungal communities were characterised by analysis of mucosal swab samples of the left and right middle meatuses via ITS2 marker amplicon sequencing on the Illumina MiSeq platform. Fungal associations with previously published bacterial community and inflammatory cytokine and cell data for this cohort (collected at the same intra-operative time point) were also investigated. RESULTS:Malassezia spp. were ubiquitous and often highly predominant. Season of sampling explained more of the variability in the data than any of the clinical parameters. The predominant Malassezia sp. was distinct in patients with cystic fibrosis compared to those without. However, distinctions in the mycobiota were not evident between any other patient groupings assessed, and few fungal-bacterial or fungal-inflammatory associations were observed. CONCLUSIONS:This study confirms the prominent place of Malassezia spp. within the upper respiratory tract. Overall, few distinctions between patient groups were evident, and these data lend further support to the hypothesis that fungal community types may have no direct causative association with idiopathic CRS. Additional studies incorporating a broader array of inflammatory markers are required to assess whether these ubiquitous fungi nonetheless play an exacerbating role in some sensitive individuals. en
dc.format.medium Print en
dc.language eng en
dc.relation.ispartofseries Rhinology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject Humans en
dc.subject Bacteria en
dc.subject Malassezia en
dc.subject Sinusitis en
dc.subject Rhinitis en
dc.subject Chronic Disease en
dc.subject Case-Control Studies en
dc.subject Microbiota en
dc.title The sinonasal mycobiota in chronic rhinosinusitis and control patients. en
dc.type Journal Article en
dc.identifier.doi 10.4193/rhin18.256 en
pubs.issue 3 en
pubs.begin-page 190 en
pubs.volume 57 en
dc.rights.holder Copyright: The author en
pubs.end-page 199 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Journal Article en
pubs.elements-id 774696 en Engineering en Chemical and Materials Eng en Medical and Health Sciences en School of Medicine en Surgery Department en Science en Biological Sciences en
dc.identifier.eissn 1996-8604 en
pubs.record-created-at-source-date 2019-01-05 en
pubs.dimensions-id 30609424 en

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