Anticancer Characteristics of Fomitopsis pinicola Extract in a Xenograft Mouse Model-a Preliminary Study.

Show simple item record Kao, Chi HJ en Greenwood, David en Jamieson, Stephen en Coe, Margaret E en Murray, Pamela M en Ferguson, Lynnette en Bishop, Karen en 2019-09-29T21:34:37Z en 2019-08-07 en
dc.identifier.citation Nutrition and cancer 1-8 07 Aug 2019 en
dc.identifier.issn 0163-5581 en
dc.identifier.uri en
dc.description.abstract Introduction: Medicinal mushrooms have been used for the treatment of diseases and general promotion of health for many centuries. Recent pharmacological research into medicinal mushrooms has identified various therapeutic properties, with applications in modern medicine. Aim: To evaluate the anti-cancer activities of Fomitopsis pinicola (F. pinicola) alcoholic extract in an in vivo setting. Methods: The anti-tumour effect of the F. pinicola extract was tested in a xenograft immune-compromised Rag-1 mouse model. This was followed by RT-PCR and metabolomics analyses. Results: There were no observable differences in tumor growth between treated and non-treated groups. The bioactive components were not detected in the mouse plasma or the tumor site. Conclusions: The extract was poorly absorbed; this is likely due to the timing of treatment, dosage levels and modifications made to the extract where the alcohol-based solvent was replaced with water. This, in combination with fractionation studies which identified most anti-cancer compounds to be hydrophobic, largely explained the lack of anti-cancer activities in vivo. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Nutrition and cancer en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
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dc.rights.uri en
dc.title Anticancer Characteristics of Fomitopsis pinicola Extract in a Xenograft Mouse Model-a Preliminary Study. en
dc.type Journal Article en
dc.identifier.doi 10.1080/01635581.2019.1648693 en
pubs.begin-page 1 en
dc.rights.holder Copyright: The authors en
pubs.end-page 8 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Journal Article en
pubs.elements-id 779233 en Medical and Health Sciences en Medical Sciences en Auckland Cancer Research en Pharmacology en Science en Science Research en Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1532-7914 en
pubs.record-created-at-source-date 2019-08-08 en
pubs.dimensions-id 31387396 en

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