dc.contributor.author |
Correddu, Danilo |
en |
dc.contributor.author |
Leung, Ka Ho Ivanhoe |
en |
dc.date.accessioned |
2019-10-01T20:19:09Z |
en |
dc.date.issued |
2019-06 |
en |
dc.identifier.issn |
1359-6446 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/48248 |
en |
dc.description.abstract |
Parkinson's disease (PD) is one of the most common neurodegenerative disorders. The exact cause(s) of PD is not well understood, although genetic mutations are associated with some forms of the disease. Many of these mutations, in particular those that are found in LRRK2, DJ-1, PINK1, and Parkin, are linked to the deregulation of mRNA translation, suggesting that this process is important for the onset of PD. Herein, we highlight recent studies that provide insights into the molecular mechanisms that relate mRNA translation to PD. These studies confirm the central role of translation in PD, emphasising the potential of restoring mRNA translation functionality as a new therapeutic treatment against PD, and providing novel targets for developing new chemical agents to target this disease. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Drug discovery today |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Animals |
en |
dc.subject |
Humans |
en |
dc.subject |
Parkinson Disease |
en |
dc.subject |
RNA, Messenger |
en |
dc.subject |
Pharmaceutical Preparations |
en |
dc.subject |
Protein Biosynthesis |
en |
dc.subject |
Mutation |
en |
dc.title |
Targeting mRNA translation in Parkinson's disease. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.drudis.2019.04.003 |
en |
pubs.issue |
6 |
en |
pubs.begin-page |
1295 |
en |
pubs.volume |
24 |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.end-page |
1303 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
Review |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
769980 |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Chemistry |
en |
dc.identifier.eissn |
1878-5832 |
en |
pubs.record-created-at-source-date |
2019-04-12 |
en |
pubs.dimensions-id |
30974176 |
en |