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| dc.contributor.author | Stabbing, LA | en |
| dc.contributor.author | Kavianinia, Iman | en |
| dc.contributor.author | Abbattista, Maria | en |
| dc.contributor.author | Harris, Paul | en |
| dc.contributor.author | Smaill, Jeffrey | en |
| dc.contributor.author | Patterson, Adam | en |
| dc.contributor.author | Brimble, Margaret | en |
| dc.date.accessioned | 2019-10-01T20:26:01Z | en |
| dc.date.issued | 2019-09-01 | en |
| dc.identifier.issn | 0223-5234 | en |
| dc.identifier.uri | http://hdl.handle.net/2292/48257 | en |
| dc.description.abstract | Culicinin D is a 10 amino acid peptaibol containing a rare and synthetically challenging (2S,4S,6R)-AHMOD residue, that exhibits potent antiproliferative activity against MDA-MB-468 cells. An SAR study focusing on replacement of the AHMOD residue was undertaken, culminating in the revelation that a 6-hydroxy or 6-keto substituent was essential to retain potent low nanomolar antiproliferative activity. | en |
| dc.relation.ispartofseries | European Journal of Medicinal Chemistry | en |
| dc.rights | Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. | en |
| dc.rights.uri | https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm | en |
| dc.title | Synthesis and antiproliferative activity of culicinin D analogues containing simplified AHMOD-based residues | en |
| dc.type | Journal Article | en |
| dc.identifier.doi | 10.1016/j.ejmech.2019.05.052 | en |
| pubs.begin-page | 235 | en |
| pubs.volume | 177 | en |
| dc.rights.holder | Copyright: The author | en |
| pubs.end-page | 246 | en |
| dc.rights.accessrights | http://purl.org/eprint/accessRights/RestrictedAccess | en |
| pubs.subtype | Article | en |
| pubs.elements-id | 774082 | en |
| pubs.org-id | Medical and Health Sciences | en |
| pubs.org-id | Medical Sciences | en |
| pubs.org-id | Auckland Cancer Research | en |
| pubs.org-id | Science | en |
| pubs.org-id | Biological Sciences | en |
| pubs.org-id | Chemistry | en |
| pubs.org-id | Science Research | en |
| pubs.org-id | Maurice Wilkins Centre (2010-2014) | en |
| pubs.record-created-at-source-date | 2019-06-07 | en |
| pubs.online-publication-date | 2019-05-23 | en |
| pubs.dimensions-id | 31152989 | en |
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