Pharmacokinetic–pharmacodynamic population modelling in paediatric anaesthesia and its clinical translation

Show simple item record Morse, James en Sturge, Jacqueline en Anderson, Brian en 2019-10-01T20:56:06Z en 2019-06 en
dc.identifier.issn 0952-7907 en
dc.identifier.uri en
dc.description.abstract Purpose of review Pharmacokinetic–pharmacodynamic (PKPD) population modelling has advanced adult anaesthesia. Current literature was reviewed to discern use of this analytic technique for benefit in the perioperative management of children. Recent findings Variability in drug response, selection of a dose that achieves a desired target concentration and optimizing sampling protocols for further studies are all facets of paediatric anaesthesia that have benefitted from modelling approaches. PKPD models have driven the maintenance dose rate in target-controlled infusion pumps used for total intravenous anaesthesia. Although many of the models used in these pumps were developed in adults, translation for paediatric use has followed, including subgroups, such as neonates and obese children. The use of drug effect measures (e.g. bispectral index) has improved the predictive performance of pharmacodynamic models. Simulation studies have facilitated an increase in safety by quantifying drug variability, and identifying where possible adverse drug events may occur. Summary Modelling and simulation continue to have an important role optimizing drug use during anaesthesia. Models incorporating influential covariates that better describe drug pharmacokinetics and pharmacodynamics improve anaesthetic treatments and safety in diverse populations and clarify drug role and impact. Their use developing paediatric clinical studies improves trial conduct, often with fewer subjects required for study. en
dc.publisher Lippincott, Williams & Wilkins en
dc.relation.ispartofseries Current Opinion in Anesthesiology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject anaesthesia en
dc.subject children en
dc.subject modeling en
dc.subject pharmacodynamics en
dc.subject pharmacokinetics en
dc.title Pharmacokinetic–pharmacodynamic population modelling in paediatric anaesthesia and its clinical translation en
dc.type Journal Article en
dc.identifier.doi 10.1097/ACO.0000000000000725 en
pubs.issue 3 en
pubs.begin-page 352 en
pubs.volume 32 en
dc.rights.holder Copyright: The author en en
pubs.end-page 362 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 770160 en Medical and Health Sciences en Medical Sciences en Pharmacology en School of Medicine en Anaesthesiology en
pubs.record-created-at-source-date 2019-05-02 en
pubs.dimensions-id 31045640 en

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