dc.contributor.author |
Sluik, D |
en |
dc.contributor.author |
Brouwer-Brolsma, EM |
en |
dc.contributor.author |
Berendsen, AAM |
en |
dc.contributor.author |
Mikkila, V |
en |
dc.contributor.author |
Poppitt, Sally |
en |
dc.contributor.author |
Silvestre, MP |
en |
dc.contributor.author |
Tremblay, A |
en |
dc.contributor.author |
Perusse, L |
en |
dc.contributor.author |
Bouchard, C |
en |
dc.contributor.author |
Raben, A |
en |
dc.contributor.author |
Feskens, E |
en |
dc.date.accessioned |
2019-10-01T21:06:27Z |
en |
dc.date.issued |
2019-05 |
en |
dc.identifier.issn |
1938-3207 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/48304 |
en |
dc.description.abstract |
Background Data on the relationship between protein intake and the risk of type 2 diabetes are conflicting. Objective We studied prospective associations between the intake of total, plant-based, and animal protein and the risk of pre-diabetes and diabetes in 4 population-based studies included in the PREVIEW project. Methods Analyses were conducted with the use of data from 3 European cohorts and 1 Canadian cohort, including 78,851 participants. Protein intake was assessed through the use of harmonized data from food-frequency questionnaires or 3-d dietary records. Cohort-specific incidence ratios (IRs) were estimated for pre-diabetes and diabetes, adjusting for general characteristics, lifestyle and dietary factors, disease history, and body mass index (BMI) and waist circumference; results were pooled based on a random-effects meta-analysis. Results Higher total protein intake (g · kg–1 · d–1) was associated with lower incidences of pre-diabetes and diabetes (pooled IRs: 0.84; 95% CI: 0.82, 0.87 and 0.49; 95% CI: 0.28, 0.83, respectively); plant-based protein intake was the main determinant (pooled IRs: 0.83; 95% CI: 0.81, 0.86 and 0.53; 95% CI: 0.36, 0.76, respectively). Substituting 2 energy percentage (E%) protein at the expense of carbohydrates revealed increased risks of pre-diabetes and diabetes (pooled IRs: 1.04; 95% CI: 1.01, 1.07 and 1.09; 95% CI: 1.01, 1.18, respectively). Except for the associations between intakes of total protein and plant-based protein (g · kg–1 · d–1) and diabetes, all other associations became nonsignificant after adjustment for BMI and waist circumference. Conclusions Higher protein intake (g · kg–1 · d–1) was associated with a lower risk of pre-diabetes and diabetes. Associations were substantially attenuated after adjustments for BMI and waist circumference, which demonstrates a crucial role for adiposity and may account for previous conflicting findings. This study was registered at ISRCTN as ISRCTN31174892. |
en |
dc.publisher |
Oxford University Press (OUP) |
en |
dc.relation.ispartofseries |
American Journal of Clinical Nutrition |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Protein intake and the incidence of pre-diabetes and diabetes in 4 population-based studies: the PREVIEW project |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1093/ajcn/nqy388 |
en |
pubs.issue |
5 |
en |
pubs.begin-page |
1310 |
en |
pubs.volume |
109 |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.end-page |
1318 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
772492 |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Biological Sciences |
en |
pubs.record-created-at-source-date |
2019-05-17 |
en |
pubs.online-publication-date |
2019-05-03 |
en |
pubs.dimensions-id |
31051510 |
en |