Diverticulosis and nine connective tissue disorders: epidemiological support for an association.

Show simple item record

dc.contributor.author Broad, Joanna en
dc.contributor.author Wu, Zhenqiang en
dc.contributor.author Clark, Taane G en
dc.contributor.author Musson, David en
dc.contributor.author Jaung, Rebekah en
dc.contributor.author Arroll, Bruce en
dc.contributor.author Bissett, Ian en
dc.contributor.author Connolly, Martin en
dc.date.accessioned 2019-10-01T21:06:33Z en
dc.date.issued 2019-07 en
dc.identifier.issn 0300-8207 en
dc.identifier.uri http://hdl.handle.net/2292/48305 en
dc.description.abstract Purpose: An underlying connective tissue disorder (CTD) may predispose to formation of intestinal diverticula. We assess the association of diverticulosis with nine selected CTDs, to inform the pathophysiology of diverticula. Methods: A population-based period-prevalence study. Individuals (3.5 million New Zealand residents born 1901-1986) with a health system record 1999-2016 were grouped into those with a hospital diagnosis of diverticulosis or diverticulitis (ICD-10-AM K57), and those without. Also recorded were any hospital diagnoses of nine selected CTDs. The association of exposure to diverticulosis and each CTD was assessed using logistic regressions adjusted for age, gender, ethnicity and region. Results: In all, 85,958 (2.4%) people had a hospital diagnosis of diverticulosis. Hospitalisation with diverticulosis was highly significantly associated with rectal prolapse (adjusted odds ratio [OR] = 3.9), polycystic kidney disease (OR = 3.8), heritable syndromes (Marfan or Ehlers-Danlos) (OR = 2.4), female genital prolapse (OR = 2.3), non-aortic aneurysm (OR = 2.3), aortic aneurysm (OR = 2.2), inguinal hernia (OR = 1.9) and dislocations of shoulder and other joints (OR = 1.7), but not subarachnoid haemorrhage (OR = 1.0). Conclusion: People with diverticulosis are more likely to have colonic extracellular matrix (ECM)/connective tissue alterations in anatomical areas other than the bowel, suggesting linked ECM/connective tissue pathology. Although biases may exist, the results indicate large-scale integrated studies are needed to investigate underlying genetic pathophysiology of colonic diverticula, together with fundamental biological studies to investigate cellular phenotypes and ECM changes. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Connective tissue research en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Humans en
dc.subject Connective Tissue Diseases en
dc.subject Diverticulum en
dc.subject Odds Ratio en
dc.subject Adult en
dc.subject Aged en
dc.subject Aged, 80 and over en
dc.subject Middle Aged en
dc.subject Female en
dc.subject Male en
dc.title Diverticulosis and nine connective tissue disorders: epidemiological support for an association. en
dc.type Journal Article en
dc.identifier.doi 10.1080/03008207.2019.1570169 en
pubs.issue 4 en
pubs.begin-page 389 en
pubs.volume 60 en
dc.rights.holder Copyright: The author en
pubs.end-page 398 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Journal Article en
pubs.elements-id 761314 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Population Health en
pubs.org-id Gen.Practice& Primary Hlthcare en
pubs.org-id School of Medicine en
pubs.org-id Medicine Department en
pubs.org-id Surgery Department en
dc.identifier.eissn 1607-8438 en
pubs.record-created-at-source-date 2019-02-06 en
pubs.dimensions-id 30719942 en

Files in this item

There are no files associated with this item.

Find Full text

This item appears in the following Collection(s)

Show simple item record


Search ResearchSpace